Speciation of metal complexes of medicinal interest: Relationship between solution equilibria and pharmaceutical properties

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Biospeciation of essential and toxic metal ions, metal complexes with biological or medicinal activity are discussed in the paper in order to emphasize the importance of the distribution of metal ions in biological milieu. The exact knowledge of the chemical species present in the different organs/compartments/fluids/cells may provide essential information about the pharmacokinetic properties and the biological effect of the metal ion or the drug candidate metal complex. The transport of essential and toxic metal ions in the blood serum is discussed first, which is followed by the description of biodistribution of several important metal complexes with medicinal interest such as (i) anticancer, (ii) insulin-enhancing and (iii) MRI contrast agents in biological fluids.

Original languageEnglish
Pages (from-to)580-606
Number of pages27
JournalCurrent medicinal chemistry
Volume26
Issue number4
DOIs
Publication statusPublished - 2019

Keywords

  • Chemical equilibrium
  • Modeling calculation
  • Serum proteins
  • Solution stability
  • Species distribution
  • Therapeutic metallodrugs

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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