Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum

Tamás Kiss, Erzsébet Kiss, Eugenio Garribba, Hiromu Sakurai

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate)2, VO(picolinate)2 and VO(6-Me-picolinate)2, in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their ternary complexes formed with the most important low molecular mass binders in the serum: oxalic acid, lactic acid, citric acid and phosphate. The binding capabilities of two high molecular mass serum proteins, albumin and transferrin, were also taken into account. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume80
Issue number1-2
DOIs
Publication statusPublished - May 30 2000

Keywords

  • Blood serum
  • Insulin-mimetic VO(IV)
  • VO(IV)-containing drugs

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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