Speciation and structural aspects of interactions of Al(III) with small biomolecules

Patrice Rubini, Andrea Lakatos, Delphine Champmartin, Tamas Kiss

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Complexes formed with low molecular mass biomolecules are the 'dynamic or mobile units' of Al(III), which may be involved in the absorption and transport processes of this toxic element in organisms. This paper reviews the interactions of Al(III), from speciation and structural aspects, with biologically relevant endogenous and exogenous small biomolecules such as inorganic ligands (hydroxide, fluoride, (oligo)phosphates and silicic acid), amino acids, phosphorylated amino acids, oligopeptides, biophosphates including nucleotides, phosphonates, hydroxamates, and aromatic and aliphatic hydroxycarboxylates. The importance of time in biospeciation is demonstrated on the examples of binary and ternary systems involving Al(III) and citric acid. Examples are also given for the implications of the speciation of Al(III) with such small biomolecules in biology.

Original languageEnglish
Pages (from-to)137-152
Number of pages16
JournalCoordination Chemistry Reviews
Volume228
Issue number2
DOIs
Publication statusPublished - Jun 3 2002

Keywords

  • Al(III) complexes
  • Aluminium biospeciation
  • Low molecular mass biomolecules

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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