Spatial organization of cofilin in dendritic spines

B. Rácz, R. J. Weinberg

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Synaptic plasticity is associated with morphological changes in dendritic spines. The actin-based cytoskeleton plays a key role in regulating spine structure, and actin reorganization in spines is critical for the maintenance of long term potentiation. To test the hypothesis that a stable pool of F-actin rests in the spine "core," while a dynamic pool lies peripherally in its "shell," we performed immunoelectron microscopy in the stratum radiatum of rat hippocampus to elucidate the subcellular distribution of cofilin, an actin-depolymerizing protein that mediates reorganization of the actin cytoskeleton. We provide direct evidence that cofilin in spines avoids the core, and instead concentrates in the shell and within the postsynaptic density. These data suggest that cofilin may link synaptic plasticity to the actin remodeling that underlies changes in spine morphology.

Original languageEnglish
Pages (from-to)447-456
Number of pages10
JournalNeuroscience
Volume138
Issue number2
DOIs
Publication statusPublished - 2006

Fingerprint

Actin Depolymerizing Factors
Dendritic Spines
Spine
Actins
Neuronal Plasticity
Actin Cytoskeleton
Post-Synaptic Density
Immunoelectron Microscopy
Long-Term Potentiation
Hippocampus
Maintenance

Keywords

  • Actin
  • Anatomy
  • Cytoskeleton
  • Electron microscopy
  • NMDA
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spatial organization of cofilin in dendritic spines. / Rácz, B.; Weinberg, R. J.

In: Neuroscience, Vol. 138, No. 2, 2006, p. 447-456.

Research output: Contribution to journalArticle

Rácz, B. ; Weinberg, R. J. / Spatial organization of cofilin in dendritic spines. In: Neuroscience. 2006 ; Vol. 138, No. 2. pp. 447-456.
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