Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model

Balázs Könny, T. Czárán

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The coexistence of macromolecular replicators and thus the stability of presumed prebiotic replicator communities have been shown to critically depend on spatially constrained catalytic cooperation among RNA-like modular replicators. The necessary spatial constraints might have been supplied by mineral surfaces initially, preceding the more effective compartmentalization in membrane vesicles which must have been a later development of chemical evolution. Results: Using our surface-bound RNA world model - the Metabolic Replicator Model (MRM) platform - we show that the mobilities on the mineral substrate surface of both the macromolecular replicators and the small molecules of metabolites they produce catalytically are the key factors determining the stable persistence of an evolvable metabolic replicator community. Conclusion: The effects of replicator mobility and metabolite diffusion on different aspects of replicator coexistence in MRM are determined, including the maximum attainable size of the metabolic replicator system and its resistance to the invasion of parasitic replicators. We suggest a chemically plausible hypothetical scenario for the evolution of the first protocell starting from the surface-bound MRM system.

Original languageEnglish
Article number204
JournalBMC Evolutionary Biology
Volume13
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Prebiotics
prebiotics
coexistence
Minerals
RNA
Chemical Evolution
Artificial Cells
metabolite
metabolites
minerals
compartmentalization
Membranes
mineral
vesicle
persistence
membrane
substrate
world

Keywords

  • Coexistence
  • Metabolic model
  • Parasite
  • Prebiotic genome size
  • Prebiotic replicators
  • RNA world

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Medicine(all)

Cite this

Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model. / Könny, Balázs; Czárán, T.

In: BMC Evolutionary Biology, Vol. 13, No. 1, 204, 2013.

Research output: Contribution to journalArticle

@article{34626b1c41c64834a459c1d756707a2d,
title = "Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model",
abstract = "Background: The coexistence of macromolecular replicators and thus the stability of presumed prebiotic replicator communities have been shown to critically depend on spatially constrained catalytic cooperation among RNA-like modular replicators. The necessary spatial constraints might have been supplied by mineral surfaces initially, preceding the more effective compartmentalization in membrane vesicles which must have been a later development of chemical evolution. Results: Using our surface-bound RNA world model - the Metabolic Replicator Model (MRM) platform - we show that the mobilities on the mineral substrate surface of both the macromolecular replicators and the small molecules of metabolites they produce catalytically are the key factors determining the stable persistence of an evolvable metabolic replicator community. Conclusion: The effects of replicator mobility and metabolite diffusion on different aspects of replicator coexistence in MRM are determined, including the maximum attainable size of the metabolic replicator system and its resistance to the invasion of parasitic replicators. We suggest a chemically plausible hypothetical scenario for the evolution of the first protocell starting from the surface-bound MRM system.",
keywords = "Coexistence, Metabolic model, Parasite, Prebiotic genome size, Prebiotic replicators, RNA world",
author = "Bal{\'a}zs K{\"o}nny and T. Cz{\'a}r{\'a}n",
year = "2013",
doi = "10.1186/1471-2148-13-204",
language = "English",
volume = "13",
journal = "BMC Evolutionary Biology",
issn = "1471-2148",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model

AU - Könny, Balázs

AU - Czárán, T.

PY - 2013

Y1 - 2013

N2 - Background: The coexistence of macromolecular replicators and thus the stability of presumed prebiotic replicator communities have been shown to critically depend on spatially constrained catalytic cooperation among RNA-like modular replicators. The necessary spatial constraints might have been supplied by mineral surfaces initially, preceding the more effective compartmentalization in membrane vesicles which must have been a later development of chemical evolution. Results: Using our surface-bound RNA world model - the Metabolic Replicator Model (MRM) platform - we show that the mobilities on the mineral substrate surface of both the macromolecular replicators and the small molecules of metabolites they produce catalytically are the key factors determining the stable persistence of an evolvable metabolic replicator community. Conclusion: The effects of replicator mobility and metabolite diffusion on different aspects of replicator coexistence in MRM are determined, including the maximum attainable size of the metabolic replicator system and its resistance to the invasion of parasitic replicators. We suggest a chemically plausible hypothetical scenario for the evolution of the first protocell starting from the surface-bound MRM system.

AB - Background: The coexistence of macromolecular replicators and thus the stability of presumed prebiotic replicator communities have been shown to critically depend on spatially constrained catalytic cooperation among RNA-like modular replicators. The necessary spatial constraints might have been supplied by mineral surfaces initially, preceding the more effective compartmentalization in membrane vesicles which must have been a later development of chemical evolution. Results: Using our surface-bound RNA world model - the Metabolic Replicator Model (MRM) platform - we show that the mobilities on the mineral substrate surface of both the macromolecular replicators and the small molecules of metabolites they produce catalytically are the key factors determining the stable persistence of an evolvable metabolic replicator community. Conclusion: The effects of replicator mobility and metabolite diffusion on different aspects of replicator coexistence in MRM are determined, including the maximum attainable size of the metabolic replicator system and its resistance to the invasion of parasitic replicators. We suggest a chemically plausible hypothetical scenario for the evolution of the first protocell starting from the surface-bound MRM system.

KW - Coexistence

KW - Metabolic model

KW - Parasite

KW - Prebiotic genome size

KW - Prebiotic replicators

KW - RNA world

UR - http://www.scopus.com/inward/record.url?scp=84884311210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884311210&partnerID=8YFLogxK

U2 - 10.1186/1471-2148-13-204

DO - 10.1186/1471-2148-13-204

M3 - Article

VL - 13

JO - BMC Evolutionary Biology

JF - BMC Evolutionary Biology

SN - 1471-2148

IS - 1

M1 - 204

ER -