Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats

A. Körner, G. Celsi, A. C. Eklöf, T. Linné, B. Persson, A. Aperia

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The effects of aldose reductase inhibition on kidney function were studied in rats with streptozotocin-induced diabetes mellitus. Diabetic rats were fed sorbinil (20 and 50 mg/kg) by daily gastric gavage and were compared with untreated diabetic rats and normal rats. The rats were under daily supervision with regard to blood glucose control, insulin administration and body weight. The aim was to promote continuous body growth and to maintain the blood glucose concentration at around 22 mmol/l without large day-to-day fluctuations. The renal functional changes observed in this well-established diabetic model closely resembled those reported in human Type 1 (insulin-dependent) diabetes mellitus. Sorbinil treatment completely prevented renal cortical sorbitol accumulation, but did not abolish kidney enlargement or the increase in ultrafiltration pressure and glomerular filtration rate. Albumin excretion was increased to the same extent in the sorbinil-treated and in the untreated diabetic rats. We conclude that increased metabolism of glucose to sorbitol does not cause the hyperfiltration in rats with streptozotocin-induced diabetes.

Original languageEnglish
Pages (from-to)414-418
Number of pages5
JournalDiabetologia: Clinical and Experimental Diabetes and Metabolism
Volume35
Issue number5
DOIs
Publication statusPublished - May 1992

Keywords

  • Streptozotocin diabetic rat
  • albuminuria
  • aldose reductase inhibition
  • glomerular filtration rate
  • ultrafiltration pressure

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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