Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats

A. Körner, G. Celsi, A. C. Eklöf, T. Linné, B. Persson, A. Aperia

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The effects of aldose reductase inhibition on kidney function were studied in rats with streptozotocin-induced diabetes mellitus. Diabetic rats were fed sorbinil (20 and 50 mg/kg) by daily gastric gavage and were compared with untreated diabetic rats and normal rats. The rats were under daily supervision with regard to blood glucose control, insulin administration and body weight. The aim was to promote continuous body growth and to maintain the blood glucose concentration at around 22 mmol/1 without large day-to-day fluctuations. The renal functional changes observed in this well-established diabetic model closely resembled those reported in human Type 1 (insulin-dependent) diabetes mellitus. Sorbinil treatment completely prevented renal cortical sorbitol accumulation, but did not abolish kidney enlargement or the increase in ultrafiltration pressure and glomerular filtration rate. Albumin excretion was increased to the same extent in the sorbinil-treated and in the untreated diabetic rats. We conclude that increased metabolism of glucose to sorbitol does not cause the hyperfiltration in rats with streptozotocin-induced diabetes.

Original languageEnglish
Pages (from-to)414-418
Number of pages5
JournalDiabetologia
Volume35
Issue number5
Publication statusPublished - May 1992

Fingerprint

Albuminuria
Ultrafiltration
Streptozocin
Pressure
Kidney
Experimental Diabetes Mellitus
Sorbitol
Blood Glucose
Aldehyde Reductase
sorbinil
Glomerular Filtration Rate
Type 1 Diabetes Mellitus
Albumins
Stomach
Diabetes Mellitus
Body Weight
Insulin
Glucose
Growth

Keywords

  • Albuminuria
  • Aldose reductase inhibition
  • Glomerular filtration rate
  • Streptozotocin diabetic rat
  • Ultrafiltration pressure

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats. / Körner, A.; Celsi, G.; Eklöf, A. C.; Linné, T.; Persson, B.; Aperia, A.

In: Diabetologia, Vol. 35, No. 5, 05.1992, p. 414-418.

Research output: Contribution to journalArticle

Körner, A, Celsi, G, Eklöf, AC, Linné, T, Persson, B & Aperia, A 1992, 'Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats', Diabetologia, vol. 35, no. 5, pp. 414-418.
Körner, A. ; Celsi, G. ; Eklöf, A. C. ; Linné, T. ; Persson, B. ; Aperia, A. / Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats. In: Diabetologia. 1992 ; Vol. 35, No. 5. pp. 414-418.
@article{e942a6431d604fbda1f96623cdbb7180,
title = "Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats",
abstract = "The effects of aldose reductase inhibition on kidney function were studied in rats with streptozotocin-induced diabetes mellitus. Diabetic rats were fed sorbinil (20 and 50 mg/kg) by daily gastric gavage and were compared with untreated diabetic rats and normal rats. The rats were under daily supervision with regard to blood glucose control, insulin administration and body weight. The aim was to promote continuous body growth and to maintain the blood glucose concentration at around 22 mmol/1 without large day-to-day fluctuations. The renal functional changes observed in this well-established diabetic model closely resembled those reported in human Type 1 (insulin-dependent) diabetes mellitus. Sorbinil treatment completely prevented renal cortical sorbitol accumulation, but did not abolish kidney enlargement or the increase in ultrafiltration pressure and glomerular filtration rate. Albumin excretion was increased to the same extent in the sorbinil-treated and in the untreated diabetic rats. We conclude that increased metabolism of glucose to sorbitol does not cause the hyperfiltration in rats with streptozotocin-induced diabetes.",
keywords = "Albuminuria, Aldose reductase inhibition, Glomerular filtration rate, Streptozotocin diabetic rat, Ultrafiltration pressure",
author = "A. K{\"o}rner and G. Celsi and Ekl{\"o}f, {A. C.} and T. Linn{\'e} and B. Persson and A. Aperia",
year = "1992",
month = "5",
language = "English",
volume = "35",
pages = "414--418",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Sorbinil does not prevent hyperfiltration, elevated ultrafiltration pressure and albuminuria in streptozotocin-diabetic rats

AU - Körner, A.

AU - Celsi, G.

AU - Eklöf, A. C.

AU - Linné, T.

AU - Persson, B.

AU - Aperia, A.

PY - 1992/5

Y1 - 1992/5

N2 - The effects of aldose reductase inhibition on kidney function were studied in rats with streptozotocin-induced diabetes mellitus. Diabetic rats were fed sorbinil (20 and 50 mg/kg) by daily gastric gavage and were compared with untreated diabetic rats and normal rats. The rats were under daily supervision with regard to blood glucose control, insulin administration and body weight. The aim was to promote continuous body growth and to maintain the blood glucose concentration at around 22 mmol/1 without large day-to-day fluctuations. The renal functional changes observed in this well-established diabetic model closely resembled those reported in human Type 1 (insulin-dependent) diabetes mellitus. Sorbinil treatment completely prevented renal cortical sorbitol accumulation, but did not abolish kidney enlargement or the increase in ultrafiltration pressure and glomerular filtration rate. Albumin excretion was increased to the same extent in the sorbinil-treated and in the untreated diabetic rats. We conclude that increased metabolism of glucose to sorbitol does not cause the hyperfiltration in rats with streptozotocin-induced diabetes.

AB - The effects of aldose reductase inhibition on kidney function were studied in rats with streptozotocin-induced diabetes mellitus. Diabetic rats were fed sorbinil (20 and 50 mg/kg) by daily gastric gavage and were compared with untreated diabetic rats and normal rats. The rats were under daily supervision with regard to blood glucose control, insulin administration and body weight. The aim was to promote continuous body growth and to maintain the blood glucose concentration at around 22 mmol/1 without large day-to-day fluctuations. The renal functional changes observed in this well-established diabetic model closely resembled those reported in human Type 1 (insulin-dependent) diabetes mellitus. Sorbinil treatment completely prevented renal cortical sorbitol accumulation, but did not abolish kidney enlargement or the increase in ultrafiltration pressure and glomerular filtration rate. Albumin excretion was increased to the same extent in the sorbinil-treated and in the untreated diabetic rats. We conclude that increased metabolism of glucose to sorbitol does not cause the hyperfiltration in rats with streptozotocin-induced diabetes.

KW - Albuminuria

KW - Aldose reductase inhibition

KW - Glomerular filtration rate

KW - Streptozotocin diabetic rat

KW - Ultrafiltration pressure

UR - http://www.scopus.com/inward/record.url?scp=0026562114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026562114&partnerID=8YFLogxK

M3 - Article

C2 - 1521721

AN - SCOPUS:0026562114

VL - 35

SP - 414

EP - 418

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 5

ER -