Sonotherapy, antirestenotic therapeutic ultrasound in coronary arteries: The first clinical experience

E. Regar, A. Thury, W. J. Van der Giessen, G. Sianos, J. Vos, P. C. Smits, S. G. Carlier, P. De Feyter, D. P. Foley, Patrick W. Serruys

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We studied the safety and feasibility of intracoronary sonotherapy (IST) and its effect on the coronary vessel at 6 months. Thirty-seven patients with stable or unstable angina were included (40 lesions). The indication was de novo lesion (n = 26), restenosis (n = 2), in-stent restenosis (n = 11), and a total occlusion of a venous bypass graft. After successful angioplasty, IST was performed using a 5 Fr catheter with three serial ultrasound transducers operating at 1 MHz. IST was successfully performed in 36 lesions (success rate, 90%). IST exposure time per lesion was 718 ± 127 sec. During hospital stay, one patient died due to a bleeding complication. At 6-month follow-up, one patient experienced acute myocardial infarction, eight patients underwent repeat PTCA. No patient underwent CABG. Late lumen loss was 1.05 ± 0.70 mm with a restenosis rate of 25%. IVUS analysis revealed a neointima burden of 25% ± 11%. IST can be applied safely and with high acute procedural success. Sonotherapy-related major adverse events were not observed. Late lumen loss and neointimal growth were similar to conventional PTCA approaches. These results justify the initiation of randomized clinical efficacy studies.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Volume60
Issue number1
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Coronary Vessels
Therapeutics
Neointima
Stable Angina
Unstable Angina
Transducers
Angioplasty
Stents
Length of Stay
Catheters
Myocardial Infarction
Hemorrhage
Transplants
Safety
Growth

Keywords

  • Angioplasty
  • Restenosis
  • Safety
  • Sonotherapy
  • Therapeutic ultrasound

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Sonotherapy, antirestenotic therapeutic ultrasound in coronary arteries : The first clinical experience. / Regar, E.; Thury, A.; Van der Giessen, W. J.; Sianos, G.; Vos, J.; Smits, P. C.; Carlier, S. G.; De Feyter, P.; Foley, D. P.; Serruys, Patrick W.

In: Catheterization and Cardiovascular Interventions, Vol. 60, No. 1, 01.09.2003, p. 9-17.

Research output: Contribution to journalArticle

Regar, E, Thury, A, Van der Giessen, WJ, Sianos, G, Vos, J, Smits, PC, Carlier, SG, De Feyter, P, Foley, DP & Serruys, PW 2003, 'Sonotherapy, antirestenotic therapeutic ultrasound in coronary arteries: The first clinical experience', Catheterization and Cardiovascular Interventions, vol. 60, no. 1, pp. 9-17. https://doi.org/10.1002/ccd.10617
Regar, E. ; Thury, A. ; Van der Giessen, W. J. ; Sianos, G. ; Vos, J. ; Smits, P. C. ; Carlier, S. G. ; De Feyter, P. ; Foley, D. P. ; Serruys, Patrick W. / Sonotherapy, antirestenotic therapeutic ultrasound in coronary arteries : The first clinical experience. In: Catheterization and Cardiovascular Interventions. 2003 ; Vol. 60, No. 1. pp. 9-17.
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