Some new data concerning the chromatographic purity test for nifedipine

Zs Budvàri-bàràny, Gy szasz, G. Radeczky, I. Simonyi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The analysis of different Nifedipine commercial samples indicated the presence of impurities other than the nitroso- and nitrophenylpyridine analogues of Nifedipine generally are included in the pharmacopoeia-monographs. Besides the two latter photodegradation products iso-nifedipine and a tetrahydropyrimidine derivative as by--products of nifedipine-synthesis were identified. HPLC procedure is suitable for the separation Nifedipine and all of the four contaminants is published.

Original languageEnglish
Pages (from-to)3541-3551
Number of pages11
JournalJournal of Liquid Chromatography
Volume13
Issue number17
DOIs
Publication statusPublished - Jan 1 1990

ASJC Scopus subject areas

  • Molecular Medicine

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