Some lessons from the tissue transglutaminase knockout mouse

Z. Sarang, B. Tóth, Z. Balajthy, K. Köröskényi, É Garabuczi, L. Fésüs, Z. Szondy

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca2+-dependent protein modifications. It acts as a G protein in transmembrane signaling and as a cell surface adhesion mediator, this distinguishes it from other members of the transglutaminase family. The sequence motifs and domains revealed in the TG2 structure, can each be assigned distinct cellular functions, including the regulation of cytoskeleton, cell adhesion, and cell death. Though many biological functions of the enzyme have already been described or proposed previously, studies of TG2 null mice by our laboratory during the past years revealed several novel in vivo roles of the protein. In this review we will discuss these novel roles in their biological context.

Original languageEnglish
Pages (from-to)625-631
Number of pages7
JournalAmino Acids
Volume36
Issue number4
DOIs
Publication statusPublished - Apr 2009

Fingerprint

Knockout Mice
Cell Adhesion
Acyltransferases
Transglutaminases
Cell adhesion
Cell death
Cytoskeleton
GTP-Binding Proteins
Proteins
Cell Death
Adhesion
Enzymes
transglutaminase 2

Keywords

  • Heart
  • Knockout mice
  • Liver
  • Macrophage
  • Neutrophils
  • Tissue transglutaminase

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Some lessons from the tissue transglutaminase knockout mouse. / Sarang, Z.; Tóth, B.; Balajthy, Z.; Köröskényi, K.; Garabuczi, É; Fésüs, L.; Szondy, Z.

In: Amino Acids, Vol. 36, No. 4, 04.2009, p. 625-631.

Research output: Contribution to journalArticle

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