Some factors affecting metal ion-monohydroxamate interactions in aqueous solution

E. Farkas, E. Enyedy, Hajnalka Csóka

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The chelating properties exhibited by a series of monohydroxamic acids (propanohydroxamic acid (Pha), hexanohydroxamic acid (Hha), benzohydroxamic acid (Bha), N-methyl-acetohydroxamic acid (MAha), N-phenyl-acetohydroxamic acid (PhAha) and 2-hydroxypyridine-N-oxide (PYRha)) towards copper(II), nickel(II), zinc(II), calcium(II), magnesium(II) and aluminium(III) ions were studied by pH-metric, spectrophotometric and, in one case, by 27Al NMR methods. The results were compared with the corresponding data for metal ion-acetohydroxamate (Aha) and metal ion-desferrioxamine B (DFB) complexes. Changes of the substituents either on the carbon or on the nitrogen of the hydroxamate moiety caused a measurable effect on the chelate stability only in the case of aluminium(III) complexes. The aromatic derivative, PYRha, formed significantly more stable complexes than expected on the basis of the ligand basicity. The higher complex-forming ability of DFB compared to monohydroxamic acids diminishes in the case of the largest calcium(II) ion. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalJournal of Inorganic Biochemistry
Volume79
Issue number1-4
DOIs
Publication statusPublished - Apr 30 2000

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Metal ions
Deferoxamine
Metals
Ions
Aluminum
Acids
Calcium
Alkalinity
Chelation
Nickel
Magnesium
Zinc
Copper
Nitrogen
Carbon
Nuclear magnetic resonance
Ligands
Derivatives
N-methyl acetohydroxamic acid
2-hydroxypyridine-N-oxide

Keywords

  • Desferrioxamine B
  • Equilibrium studies
  • Metal complexes
  • Monohydroxamic acids
  • Stability constants

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Some factors affecting metal ion-monohydroxamate interactions in aqueous solution. / Farkas, E.; Enyedy, E.; Csóka, Hajnalka.

In: Journal of Inorganic Biochemistry, Vol. 79, No. 1-4, 30.04.2000, p. 205-211.

Research output: Contribution to journalArticle

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