Some effects of prolonged treatment with atropine on the stomach wall of the rat. (a biochemical-pharmacological approach of the effects of vagal exclusion - vagotomy and atropine treatment - on cellular-molecular level)

G. Mózsik, B. Kiss, T. Jávor, M. Krausz

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5 Citations (Scopus)

Abstract

A biochemical-pharmacological analysis of the stomach wall was made in rats chronically treated with atropine. The acid-soluble inorganic and organic phosphates, phospholipid phosphates, ribonucleic acid and deoxyribonucleic acid were measured from the membranous (rumenal) and glandular (pyloric) parts of the stomach wall. It was observed that 1) the glandular part and the membranous part of the stomach wall did not react similarly to prolonged (25 days) atropine treatment; 2) "short term" (reversible) and "long term" (irreversible) biochemical process were present in the glandular part of the stomach wall ten days after cessation of prolonged (25 days) atropine treatment. A biochemical-cellular-morphological theory was made to explain the difference between a "chemical" and a "surgical" vagotomy and for the development of drug tolerance on the stomach wall at the cellular-molecular level.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalEuropean Journal of Pharmacology
Volume7
Issue number1
Publication statusPublished - Jul 1969

Fingerprint

Vagotomy
Atropine
Stomach
Pharmacology
Biochemical Phenomena
Phosphates
Drug Tolerance
Organophosphates
Phospholipids
RNA
Acids
DNA

Keywords

  • Biochemical background of drug tolerance
  • Biochemical-cellular-morphological explanation
  • glandular parts of stomach wall
  • irreversible biochemical alterations
  • Membranous
  • nucleic acids
  • Phosphate fractions
  • Prolonged treatment with atropine
  • Reversible

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

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AU - Mózsik, G.

AU - Kiss, B.

AU - Jávor, T.

AU - Krausz, M.

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N2 - A biochemical-pharmacological analysis of the stomach wall was made in rats chronically treated with atropine. The acid-soluble inorganic and organic phosphates, phospholipid phosphates, ribonucleic acid and deoxyribonucleic acid were measured from the membranous (rumenal) and glandular (pyloric) parts of the stomach wall. It was observed that 1) the glandular part and the membranous part of the stomach wall did not react similarly to prolonged (25 days) atropine treatment; 2) "short term" (reversible) and "long term" (irreversible) biochemical process were present in the glandular part of the stomach wall ten days after cessation of prolonged (25 days) atropine treatment. A biochemical-cellular-morphological theory was made to explain the difference between a "chemical" and a "surgical" vagotomy and for the development of drug tolerance on the stomach wall at the cellular-molecular level.

AB - A biochemical-pharmacological analysis of the stomach wall was made in rats chronically treated with atropine. The acid-soluble inorganic and organic phosphates, phospholipid phosphates, ribonucleic acid and deoxyribonucleic acid were measured from the membranous (rumenal) and glandular (pyloric) parts of the stomach wall. It was observed that 1) the glandular part and the membranous part of the stomach wall did not react similarly to prolonged (25 days) atropine treatment; 2) "short term" (reversible) and "long term" (irreversible) biochemical process were present in the glandular part of the stomach wall ten days after cessation of prolonged (25 days) atropine treatment. A biochemical-cellular-morphological theory was made to explain the difference between a "chemical" and a "surgical" vagotomy and for the development of drug tolerance on the stomach wall at the cellular-molecular level.

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KW - Reversible

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