Some characteristics of the immune response to cytomegalovirus infection

E. Gönczöl, L. Vaczi, G. Kovacs, I. Matko

Research output: Contribution to journalArticle

Abstract

Thirty five patients who had been subjected to open heart surgery and had received large amounts of blood were serially tested for antibodies to cytomegalovirus (CMV). At least 7 gave an immune response characteristic of primary CMV infection. Another 7 underwent secondary or reactivated CMV infection. In the serum of the patients with primary infection, the antibodies demonstrable by the immunofluorescence (IF) method appeared earliest and reached the highest titre. Subsequently the complement fixing and finally the neutralizing antibodies became demonstrable. Among the antibodies demonstrated by the IF method, those diffusely staining the nucleus appeared earliest. These were followed by antibodies staining the perinuclear antigens and those diffusely staining the cytoplasm. The antibodies reacting with the large intranuclear granules and inclusion like antigens as well as those reacting with cytoplasmic inclusions were the last to become demonstrable.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalActa Microbiologica Academiae Scientiarum Hungaricae
Volume19
Issue number2
Publication statusPublished - 1972

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Cytomegalovirus Infections
Antibodies
Staining and Labeling
Fluorescent Antibody Technique
Antigens
Intranuclear Inclusion Bodies
Inclusion Bodies
Neutralizing Antibodies
Cytomegalovirus
Thoracic Surgery
Cytoplasm
Infection
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Some characteristics of the immune response to cytomegalovirus infection. / Gönczöl, E.; Vaczi, L.; Kovacs, G.; Matko, I.

In: Acta Microbiologica Academiae Scientiarum Hungaricae, Vol. 19, No. 2, 1972, p. 125-132.

Research output: Contribution to journalArticle

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