Some aspects of the chemistry of pyrimido[1,2-b]pyridazinones

P. Mátyus, G. Szilagyi, E. Kasztreiner, G. Rabloczky, P. Sohár

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

On reacting the 3-aminopyridazines 1a,d,e with dimethyl acetylenedicarboxylate (DMAD), the pyrimido[1,2-b]pyridazin-2(2H)-ones 2e-g, whereas starting from 1f, the 4(4H)-ones 5a and 3b,d were prepared. In the 2(2H)-one series, the reactions of 2b with various amino compounds resulted in various types of products. The reaction of N-methylaminopyridazines 1g,h with DMAD led to the endo-N-substituted derivatives 8a,b, whereas 1h with diethyl ethoxymethylenemalonate (DEM) gave the exo-N-substituted compound 1k. The constitution of the compounds was proved by spectroscopic and chemical evidences.

Original languageEnglish
Pages (from-to)1535-1542
Number of pages8
JournalJournal of Heterocyclic Chemistry
Volume25
Issue number5
Publication statusPublished - 1988

Fingerprint

Derivatives
acetylenedicarboxylic acid dimethyl ester
diethyl (ethoxymethylene)malonate
endo-alpha-sialidase
aminopyridazine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Some aspects of the chemistry of pyrimido[1,2-b]pyridazinones. / Mátyus, P.; Szilagyi, G.; Kasztreiner, E.; Rabloczky, G.; Sohár, P.

In: Journal of Heterocyclic Chemistry, Vol. 25, No. 5, 1988, p. 1535-1542.

Research output: Contribution to journalArticle

Mátyus, P, Szilagyi, G, Kasztreiner, E, Rabloczky, G & Sohár, P 1988, 'Some aspects of the chemistry of pyrimido[1,2-b]pyridazinones', Journal of Heterocyclic Chemistry, vol. 25, no. 5, pp. 1535-1542.
Mátyus, P. ; Szilagyi, G. ; Kasztreiner, E. ; Rabloczky, G. ; Sohár, P. / Some aspects of the chemistry of pyrimido[1,2-b]pyridazinones. In: Journal of Heterocyclic Chemistry. 1988 ; Vol. 25, No. 5. pp. 1535-1542.
@article{672a8440695649bf826442f5ff96f884,
title = "Some aspects of the chemistry of pyrimido[1,2-b]pyridazinones",
abstract = "On reacting the 3-aminopyridazines 1a,d,e with dimethyl acetylenedicarboxylate (DMAD), the pyrimido[1,2-b]pyridazin-2(2H)-ones 2e-g, whereas starting from 1f, the 4(4H)-ones 5a and 3b,d were prepared. In the 2(2H)-one series, the reactions of 2b with various amino compounds resulted in various types of products. The reaction of N-methylaminopyridazines 1g,h with DMAD led to the endo-N-substituted derivatives 8a,b, whereas 1h with diethyl ethoxymethylenemalonate (DEM) gave the exo-N-substituted compound 1k. The constitution of the compounds was proved by spectroscopic and chemical evidences.",
author = "P. M{\'a}tyus and G. Szilagyi and E. Kasztreiner and G. Rabloczky and P. Soh{\'a}r",
year = "1988",
language = "English",
volume = "25",
pages = "1535--1542",
journal = "Journal of Heterocyclic Chemistry",
issn = "0022-152X",
publisher = "Heterocorporation",
number = "5",

}

TY - JOUR

T1 - Some aspects of the chemistry of pyrimido[1,2-b]pyridazinones

AU - Mátyus, P.

AU - Szilagyi, G.

AU - Kasztreiner, E.

AU - Rabloczky, G.

AU - Sohár, P.

PY - 1988

Y1 - 1988

N2 - On reacting the 3-aminopyridazines 1a,d,e with dimethyl acetylenedicarboxylate (DMAD), the pyrimido[1,2-b]pyridazin-2(2H)-ones 2e-g, whereas starting from 1f, the 4(4H)-ones 5a and 3b,d were prepared. In the 2(2H)-one series, the reactions of 2b with various amino compounds resulted in various types of products. The reaction of N-methylaminopyridazines 1g,h with DMAD led to the endo-N-substituted derivatives 8a,b, whereas 1h with diethyl ethoxymethylenemalonate (DEM) gave the exo-N-substituted compound 1k. The constitution of the compounds was proved by spectroscopic and chemical evidences.

AB - On reacting the 3-aminopyridazines 1a,d,e with dimethyl acetylenedicarboxylate (DMAD), the pyrimido[1,2-b]pyridazin-2(2H)-ones 2e-g, whereas starting from 1f, the 4(4H)-ones 5a and 3b,d were prepared. In the 2(2H)-one series, the reactions of 2b with various amino compounds resulted in various types of products. The reaction of N-methylaminopyridazines 1g,h with DMAD led to the endo-N-substituted derivatives 8a,b, whereas 1h with diethyl ethoxymethylenemalonate (DEM) gave the exo-N-substituted compound 1k. The constitution of the compounds was proved by spectroscopic and chemical evidences.

UR - http://www.scopus.com/inward/record.url?scp=0023685332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023685332&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0023685332

VL - 25

SP - 1535

EP - 1542

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

SN - 0022-152X

IS - 5

ER -