Somatostatin versus Cimetidine in the Treatment of Actively Bleeding Duodenal Ulcer: A Prospective, Randomized, Controlled Trial

Zsolt Tulassay, Ramesh Gupta, Janos Papp, András Bodnár

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In a double‐blind, prospective, randomized trial, the healing effect of somatostatin was compared with that of cimetidine in 67 patients with endoscopically confirmed duodenal ulcer with active bleeding (33 patients were treated with somatostatin, 34 with cimetidine). Intravenous infusion of either drug was administered for 48 or 72 b. Somatostatin bad a bigger rate of control of bleeding (30 vs. 24 patients at 72 h; p < 0.05) and bad less mean transfusion requirements (4.4 vs. 5.8 units; p < 0.01). Need for surgical intervention and the mortality figures show a trend in favor of somatostatin. There was no difference in rebleeding rate.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalThe American Journal of Gastroenterology
Volume84
Issue number1
DOIs
Publication statusPublished - Jan 1989

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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