Somatostatin induces vasodilatation in the cat mesenteric artery via endothelium-derived nitric oxide and prostaglandins

László Dézsi, Gabriella Dörnyei, Mátyás Szentiványi, T. Tulassay, E. Monos

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Direct vascular effects of somatostatin (ST) were investigated in cat superior mesenteric artery (SMA) segments in vitro. Changes of outer diameter were measured at constant axial length and perfusion pressure. SMA segments in the resting state were not affected by ST, regardless of endothelial integrity, Noradrenaline-preconstricted SMA segments were dilated concentration-dependently by ST (EC50 10-13 mol/l). At maximal dilatation (by 10-11 mol/l ST) the preconstriction was diminished to 45 ± 9% (P <0.001). Perfusion with Triton X-100, or N(G)-nitro-L-arginine nearly abolished the ST-induced dilatation, while indomethacin treatment partially suppressed it. We conclude that ST dilates preconstricted cat SMA segments mainly via the endothelial release of nitric oxide, and additionally via prostaglandins.

Original languageEnglish
Pages (from-to)536-538
Number of pages3
JournalPflugers Archiv European Journal of Physiology
Volume433
Issue number4
DOIs
Publication statusPublished - 1997

Fingerprint

Mesenteric Arteries
Somatostatin
Vasodilation
Prostaglandins
Nitric Oxide
Cats
Superior Mesenteric Artery
Dilatation
Perfusion
Octoxynol
Indomethacin
Blood Vessels
Arginine
Norepinephrine
Pressure

Keywords

  • Endothelium dependent dilatation
  • Mesenteric artery
  • Vasoactive peptides

ASJC Scopus subject areas

  • Physiology

Cite this

Somatostatin induces vasodilatation in the cat mesenteric artery via endothelium-derived nitric oxide and prostaglandins. / Dézsi, László; Dörnyei, Gabriella; Szentiványi, Mátyás; Tulassay, T.; Monos, E.

In: Pflugers Archiv European Journal of Physiology, Vol. 433, No. 4, 1997, p. 536-538.

Research output: Contribution to journalArticle

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AU - Tulassay, T.

AU - Monos, E.

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