The cortical-striatal-thalamic circuit modulates cognitive processing and thus may be involved in the cognitive dysfunction in schizophrenia. Coronal brain slices from 15 schizophrenic patients and 13 control subjects were immunoreacted against somatostatin. Interneuronal cell densities were calculated bilaterally from striatum (caudate nucleus, putamen and nucleus accumbens). After adjusting for area and slice thickness, the cell densities were calculated and compared within groups. Statistical analysis comparing schizophrenic patients with control subjects elicited that mean somatostatin- positive cell densities were reduced in schizophrenics in all areas. However, statistical analysis for factor diagnosis employing ANOVA revealed significant values only in left putamen and left and right caudate (p<0.05). Surprisingly, there was an concomitant gender effect in these areas. These observations suggest that there is no evidence for an overall statistical significant loss of somatostatin expression in schizophrenia.
|Number of pages||6|
|Journal||Neurology Psychiatry and Brain Research|
|Publication status||Published - Dec 1 1998|
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health