Somatostatin cell densities in the striatum in schizophrenic patients and control subjects

Peter Falkai, William G. Honer, U. Taperon-Franz, Bernhard Bogerts, Catherine Majtenyi, Thomas A. Bayer

Research output: Contribution to journalArticle

Abstract

The cortical-striatal-thalamic circuit modulates cognitive processing and thus may be involved in the cognitive dysfunction in schizophrenia. Coronal brain slices from 15 schizophrenic patients and 13 control subjects were immunoreacted against somatostatin. Interneuronal cell densities were calculated bilaterally from striatum (caudate nucleus, putamen and nucleus accumbens). After adjusting for area and slice thickness, the cell densities were calculated and compared within groups. Statistical analysis comparing schizophrenic patients with control subjects elicited that mean somatostatin- positive cell densities were reduced in schizophrenics in all areas. However, statistical analysis for factor diagnosis employing ANOVA revealed significant values only in left putamen and left and right caudate (p<0.05). Surprisingly, there was an concomitant gender effect in these areas. These observations suggest that there is no evidence for an overall statistical significant loss of somatostatin expression in schizophrenia.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalNeurology Psychiatry and Brain Research
Volume6
Issue number3
Publication statusPublished - Dec 1 1998

    Fingerprint

Keywords

  • Immunohistochemistry
  • Post-mortem
  • Schizophrenia
  • Somatostatin
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Falkai, P., Honer, W. G., Taperon-Franz, U., Bogerts, B., Majtenyi, C., & Bayer, T. A. (1998). Somatostatin cell densities in the striatum in schizophrenic patients and control subjects. Neurology Psychiatry and Brain Research, 6(3), 161-166.