Somatostatin and (d-TRP8, d-CYS14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats

L. Vécsei, Ibolya Bollók, B. Penke, G. Telegdy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In the present study the effects of somatostatin and its analogs on active avoidance behavior, electroconvulsive shock (ECS)-induced retrograde amnesia, and spatial-discrimination learning were compared in rats. (d-Trp8, d-Cys14)-somatostatin (as did the somatostatin molecule itself) delayed the extinction of active avoidance behavior, antagonized ECS-induced amnesia, and did not modify spatial-discrimination learning. Des-Asn5-(d-Trp8, d-Ser13) somatostatin and des-AA1,2,4,5,12,13,-(d-Trp8) somatostatin did not influence these behaviors. The data suggest that certain parts of the somatostatin molecule are important for its behavioral actions.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalPsychoneuroendocrinology
Volume11
Issue number1
DOIs
Publication statusPublished - 1986

Fingerprint

Electroshock
Amnesia
Somatostatin
Avoidance Learning
Discrimination Learning
Retrograde Amnesia
Psychological Extinction

Keywords

  • amnesia
  • extinction
  • Somatostatin analogs
  • spatial-discrimination

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

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T1 - Somatostatin and (d-TRP8, d-CYS14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats

AU - Vécsei, L.

AU - Bollók, Ibolya

AU - Penke, B.

AU - Telegdy, G.

PY - 1986

Y1 - 1986

N2 - In the present study the effects of somatostatin and its analogs on active avoidance behavior, electroconvulsive shock (ECS)-induced retrograde amnesia, and spatial-discrimination learning were compared in rats. (d-Trp8, d-Cys14)-somatostatin (as did the somatostatin molecule itself) delayed the extinction of active avoidance behavior, antagonized ECS-induced amnesia, and did not modify spatial-discrimination learning. Des-Asn5-(d-Trp8, d-Ser13) somatostatin and des-AA1,2,4,5,12,13,-(d-Trp8) somatostatin did not influence these behaviors. The data suggest that certain parts of the somatostatin molecule are important for its behavioral actions.

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