Somatostain versus cimetidine in the treatment of actively bleeding duodenal ulcer: A prospective, randomized, controlled trial

Z. Tulassay, R. Gupta, J. Papp, A. Bodnar

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24 Citations (Scopus)

Abstract

In a double-blind, prospective, randomized trial, the healing effect of somatostatin was compared with that of cimetidine in 67 patients with endoscopically confirmed duodenal ulcer with active bleeding (33 patients were treated with somatostatin, 34 with cimetidine). Intravenous infusion of either drug was administered for 48 or 72 h. Somatostatin had a higher rate of control of bleeding (30 vs. 24 patients at 72 h; p <0.05) and had less mean transfusion requirements (4.4 vs. 5.8 units; p <0.01). Need for surgical intervention and the mortality figures show a trend in favor of somatostatin. There was no difference in rebleeding rate.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume84
Issue number1
Publication statusPublished - 1989

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Cimetidine
Duodenal Ulcer
Somatostatin
Randomized Controlled Trials
Hemorrhage
Intravenous Infusions
Therapeutics
Mortality
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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AU - Bodnar, A.

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