Somatic cell nuclear transfer: Recent progress and challenges

A. Dinnyés, Paul De Sousa, Tim King, Ian Wilmut

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Somatic cell nuclear transfer (NT) offers new and exciting opportunities in many areas of research and biotechnology. However, the field as a whole is still in its infancy, with continuing inefficiencies in the process proving many early expectations premature. The technical steps of NT are complex, and success is highly susceptible to minor variations. Furthermore, the biological process of reprogramming is not fully understood, making it difficult to optimize the protocols for providing ideal recipient oocytes and donor cells. In this paper, we describe recent advances and novel approaches, which resulted in progress during the last year, including the birth of cloned piglets and farm animals with precise genetic changes. Key problems hindering further progress are addressed.

Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalCloning and Stem Cells
Volume4
Issue number1
Publication statusPublished - 2002

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Biological Phenomena
Domestic Animals
Biotechnology
Oocytes
Parturition
Research

ASJC Scopus subject areas

  • Biotechnology
  • Developmental Biology
  • Applied Microbiology and Biotechnology

Cite this

Dinnyés, A., De Sousa, P., King, T., & Wilmut, I. (2002). Somatic cell nuclear transfer: Recent progress and challenges. Cloning and Stem Cells, 4(1), 81-90.

Somatic cell nuclear transfer : Recent progress and challenges. / Dinnyés, A.; De Sousa, Paul; King, Tim; Wilmut, Ian.

In: Cloning and Stem Cells, Vol. 4, No. 1, 2002, p. 81-90.

Research output: Contribution to journalArticle

Dinnyés, A, De Sousa, P, King, T & Wilmut, I 2002, 'Somatic cell nuclear transfer: Recent progress and challenges', Cloning and Stem Cells, vol. 4, no. 1, pp. 81-90.
Dinnyés, A. ; De Sousa, Paul ; King, Tim ; Wilmut, Ian. / Somatic cell nuclear transfer : Recent progress and challenges. In: Cloning and Stem Cells. 2002 ; Vol. 4, No. 1. pp. 81-90.
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