Solvent‐dependent reversible rearrangement of 4‐(hydroxyimino)hexahydro‐pyrimidines to 4‐aminotetrahydropyrimidine 3‐oxides

Dezső Korbonits, Erzsébet Tóbiás‐Héja, Kálmán Simon, P. Kolonits

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1,2‐Disubstituted 4‐hydroxyiminohexahydropyrimidines (8) isomerize in alcohols to yield 1,2‐disubstituted 4‐aminotetra‐hydropyrimidine 3‐oxides (9). In aprotic solvents the opposite transformation (9→8) takes place, presumably by a different mechanism. The structure of the N‐oxide 9a was confirmed by an X‐ray crystallographic analysis. (Formula Presented.)

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalLiebigs Annalen der Chemie
Volume1994
Issue number1
DOIs
Publication statusPublished - 1994

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Alcohols
X-Rays

Keywords

  • Amide oximes
  • Oximes
  • Pyrimidine N‐oxides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Solvent‐dependent reversible rearrangement of 4‐(hydroxyimino)hexahydro‐pyrimidines to 4‐aminotetrahydropyrimidine 3‐oxides. / Korbonits, Dezső; Tóbiás‐Héja, Erzsébet; Simon, Kálmán; Kolonits, P.

In: Liebigs Annalen der Chemie, Vol. 1994, No. 1, 1994, p. 19-22.

Research output: Contribution to journalArticle

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