Solvent-free synthesis of 1-(hydroxyquinolyl)- and 1-(hydroxyisoquinolyl)- 1,2,3,4-tetrahydroisoquinolines by modified mannich reaction

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Abstract

The solvent-free synthesis of 1-(hydroxyquinolyl)- and 1- (hydroxyisoquinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives is reported. The tested reaction conditions involved classical heating at 80-100 C and microwave agitation at the same temperature. Both reaction conditions yielded the compounds in good yield (57-92%), but the use of microwave conditions allowed the reaction time to be decreased.

Original languageEnglish
Pages (from-to)745-748
Number of pages4
JournalSynthesis
Issue number5
DOIs
Publication statusPublished - 2011

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Tetrahydroisoquinolines
Microwaves
Derivatives
Heating
Temperature
1,2,3,4-tetrahydroisoquinoline

Keywords

  • bioorganic chemistry
  • heterocycles
  • Mannich bases
  • multicomponent reaction
  • nucleophilic addition

ASJC Scopus subject areas

  • Organic Chemistry
  • Catalysis

Cite this

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abstract = "The solvent-free synthesis of 1-(hydroxyquinolyl)- and 1- (hydroxyisoquinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives is reported. The tested reaction conditions involved classical heating at 80-100 C and microwave agitation at the same temperature. Both reaction conditions yielded the compounds in good yield (57-92{\%}), but the use of microwave conditions allowed the reaction time to be decreased.",
keywords = "bioorganic chemistry, heterocycles, Mannich bases, multicomponent reaction, nucleophilic addition",
author = "I. Szatm{\'a}ri and F. F{\"u}l{\"o}p",
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language = "English",
pages = "745--748",
journal = "Synthesis",
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AU - Szatmári, I.

AU - Fülöp, F.

PY - 2011

Y1 - 2011

N2 - The solvent-free synthesis of 1-(hydroxyquinolyl)- and 1- (hydroxyisoquinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives is reported. The tested reaction conditions involved classical heating at 80-100 C and microwave agitation at the same temperature. Both reaction conditions yielded the compounds in good yield (57-92%), but the use of microwave conditions allowed the reaction time to be decreased.

AB - The solvent-free synthesis of 1-(hydroxyquinolyl)- and 1- (hydroxyisoquinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives is reported. The tested reaction conditions involved classical heating at 80-100 C and microwave agitation at the same temperature. Both reaction conditions yielded the compounds in good yield (57-92%), but the use of microwave conditions allowed the reaction time to be decreased.

KW - bioorganic chemistry

KW - heterocycles

KW - Mannich bases

KW - multicomponent reaction

KW - nucleophilic addition

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