Solvent-free N-alkylation of 1,3,5-triaza-7

phospha-adamantane (PTA)

Antal Udvardy, Csenge Tamara Szolnoki, Ferenc Joó, A. Kathó

Research output: Contribution to journalArticle

Abstract

1,3,5-triaza-7-phosphaadamantane was alkylated under solvent-free conditions with CH3I, CH3-(CH2)3-Br, Br-(CH2)4-Br, OH-CH2-CH2Br, and CH3CH2OOCCH2Br in a planetary ball mill with yields over 90%. Due to spontaneous resolution, both 1-(2-ethoxy-2-oxoethyl)-3,5-diaza-1-azonia-3,5-diaza-7-phosphaadamantane bromide (4) and (4-bromobutyl)-1-azonia-3,5-diaza-7-phosphaadamantane bromide (5) were obtained in the solid state as conglomerates of enantiomorphic crystals.

Original languageEnglish
Pages (from-to)469-470
Number of pages2
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume194
Issue number4-6
DOIs
Publication statusPublished - May 27 2019

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Adamantane
Alkylation
Bromides
Ball mills
Crystals

Keywords

  • ball-mill
  • N-alkylation
  • PTA
  • solvent-free

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Solvent-free N-alkylation of 1,3,5-triaza-7 : phospha-adamantane (PTA). / Udvardy, Antal; Szolnoki, Csenge Tamara; Joó, Ferenc; Kathó, A.

In: Phosphorus, Sulfur and Silicon and the Related Elements, Vol. 194, No. 4-6, 27.05.2019, p. 469-470.

Research output: Contribution to journalArticle

Udvardy, Antal ; Szolnoki, Csenge Tamara ; Joó, Ferenc ; Kathó, A. / Solvent-free N-alkylation of 1,3,5-triaza-7 : phospha-adamantane (PTA). In: Phosphorus, Sulfur and Silicon and the Related Elements. 2019 ; Vol. 194, No. 4-6. pp. 469-470.
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