Solutol and Cremophor products as new additives in suppository formulation

Szilvia Berkó, Géza Regdon, István Erös

Research output: Contribution to journalArticle

2 Citations (Scopus)


Our research has a double purpose. On the one hand, doctors have expressed the need to formulate a rectal suppository dosage form from diuretic ethacrynic acid, which would add to the choice of treatment methods and thereby increase the possibilities of individual cure. On the other hand, the liberation and thereby the bioavailability of poorly-soluble ethacrynic acid needs to be enhanced, and for this purpose solubility-increasing additives new to rectal therapy were used. Solutol HS 15, Cremophor RH 40, and Cremophor RH 60 were used as additives in concentrations of 1, 3, 5, and 10%. The quantity of drug released changed as a function of additive concentration. Depending on the acceptor phase, the best results were achieved with an additive concentration of 1-3%, which is related to the optimal additive quantity accumulated on the boundary surface.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalDrug development and industrial pharmacy
Issue number2
Publication statusPublished - Mar 23 2002


  • Cremophor RH 40
  • Cremophor RH 60
  • Ethacrynic acid
  • Solutol HS 15
  • Suppository

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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