Solution equilibrium characterization of insulin-mimetic Zn(II) complexes

T. Jakusch, K. Gajda-Schrantz, Y. Adachi, H. Sakurai, T. Kiss, L. Horváth

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Solution speciation (stoichiometry and stability constants) of the insulin mimetic Zn(II) complexes of several bidentate ligands with (O,O), (N,O) or (S,O) coordination modes have been determined by pH-metry at 25 °C and I = 0.2 M (KCl). All ligands were found to coordinate in a bidentate way forming mono, bis and tris complexes, besides a mixed hydroxo bis complex ZnL2(OH) detected in the slightly basic pH range together with the tris complex. Relationships between the stability data, lipophilicity of the complexes and earlier biological data are evaluated. The validity of the linear free energy relationships (LFER) between the proton and Zn(II) complexes and also between the VO(IV) and Zn(II) complexes is tested.

Original languageEnglish
Pages (from-to)1521-1526
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume100
Issue number9
DOIs
Publication statusPublished - Sep 2006

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Insulin
Ligands
Stoichiometry
Free energy
Protons
Bistris

Keywords

  • Insulin mimetic complexes
  • LFER
  • Speciation
  • Zn(II)-VO(IV) complexes

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Solution equilibrium characterization of insulin-mimetic Zn(II) complexes. / Jakusch, T.; Gajda-Schrantz, K.; Adachi, Y.; Sakurai, H.; Kiss, T.; Horváth, L.

In: Journal of Inorganic Biochemistry, Vol. 100, No. 9, 09.2006, p. 1521-1526.

Research output: Contribution to journalArticle

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AU - Kiss, T.

AU - Horváth, L.

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