Solution equilibria and structural characterisation of the palladium(II) and mixed metal complexes of peptides containing methionyl residues

B. Bóka, Z. Nagy, K. Várnagy, I. Sóvágó

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18 Citations (Scopus)

Abstract

Palladium(II) complexes of the peptides GlyMet, GlyMetGly and GlyGlyMet containing methionyl residues were studied by potentiometric and 1H NMR spectroscopic methods. The coordination of terminal amino and deprotonated amide nitrogen and thioether sulfur donor atoms was suggested in the mono complexes of GlyMet and GlyMetGly. The fourth coordination site of these complexes can be occupied by solvent molecule, chloride or hydroxide ions or by another ligand molecule in the bis or mixed ligand complexes. The second ligand coordinates monodentately via the thioether function in acidic media and the amino group under neutral or basic conditions. The stoichiometry of the major species formed in the palladium(II)-GlyGlyMet system is [PdH-2L]- and this is coordinated by the amino, two-amide and the thioether donor functions. Thioether bridged mixed metal complexes formed in the reaction of [Pd(dien)]2+ and [Cu(GlyMetH-1)] or [Ni(GlyMetGlyH-2)]- also have been detected by spectroscopic techniques.

Original languageEnglish
Pages (from-to)77-89
Number of pages13
JournalJournal of Inorganic Biochemistry
Volume83
Issue number2-3
DOIs
Publication statusPublished - Jan 15 2001

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Coordination Complexes
Palladium
Sulfides
Peptides
Ligands
Amides
Molecules
Sulfur
Stoichiometry
Chlorides
Nitrogen
Nuclear magnetic resonance
Atoms

Keywords

  • Methionine peptides
  • Mixed metal complex
  • NMR
  • Palladium(II)
  • Potentiometry

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

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abstract = "Palladium(II) complexes of the peptides GlyMet, GlyMetGly and GlyGlyMet containing methionyl residues were studied by potentiometric and 1H NMR spectroscopic methods. The coordination of terminal amino and deprotonated amide nitrogen and thioether sulfur donor atoms was suggested in the mono complexes of GlyMet and GlyMetGly. The fourth coordination site of these complexes can be occupied by solvent molecule, chloride or hydroxide ions or by another ligand molecule in the bis or mixed ligand complexes. The second ligand coordinates monodentately via the thioether function in acidic media and the amino group under neutral or basic conditions. The stoichiometry of the major species formed in the palladium(II)-GlyGlyMet system is [PdH-2L]- and this is coordinated by the amino, two-amide and the thioether donor functions. Thioether bridged mixed metal complexes formed in the reaction of [Pd(dien)]2+ and [Cu(GlyMetH-1)] or [Ni(GlyMetGlyH-2)]- also have been detected by spectroscopic techniques.",
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T1 - Solution equilibria and structural characterisation of the palladium(II) and mixed metal complexes of peptides containing methionyl residues

AU - Bóka, B.

AU - Nagy, Z.

AU - Várnagy, K.

AU - Sóvágó, I.

PY - 2001/1/15

Y1 - 2001/1/15

N2 - Palladium(II) complexes of the peptides GlyMet, GlyMetGly and GlyGlyMet containing methionyl residues were studied by potentiometric and 1H NMR spectroscopic methods. The coordination of terminal amino and deprotonated amide nitrogen and thioether sulfur donor atoms was suggested in the mono complexes of GlyMet and GlyMetGly. The fourth coordination site of these complexes can be occupied by solvent molecule, chloride or hydroxide ions or by another ligand molecule in the bis or mixed ligand complexes. The second ligand coordinates monodentately via the thioether function in acidic media and the amino group under neutral or basic conditions. The stoichiometry of the major species formed in the palladium(II)-GlyGlyMet system is [PdH-2L]- and this is coordinated by the amino, two-amide and the thioether donor functions. Thioether bridged mixed metal complexes formed in the reaction of [Pd(dien)]2+ and [Cu(GlyMetH-1)] or [Ni(GlyMetGlyH-2)]- also have been detected by spectroscopic techniques.

AB - Palladium(II) complexes of the peptides GlyMet, GlyMetGly and GlyGlyMet containing methionyl residues were studied by potentiometric and 1H NMR spectroscopic methods. The coordination of terminal amino and deprotonated amide nitrogen and thioether sulfur donor atoms was suggested in the mono complexes of GlyMet and GlyMetGly. The fourth coordination site of these complexes can be occupied by solvent molecule, chloride or hydroxide ions or by another ligand molecule in the bis or mixed ligand complexes. The second ligand coordinates monodentately via the thioether function in acidic media and the amino group under neutral or basic conditions. The stoichiometry of the major species formed in the palladium(II)-GlyGlyMet system is [PdH-2L]- and this is coordinated by the amino, two-amide and the thioether donor functions. Thioether bridged mixed metal complexes formed in the reaction of [Pd(dien)]2+ and [Cu(GlyMetH-1)] or [Ni(GlyMetGlyH-2)]- also have been detected by spectroscopic techniques.

KW - Methionine peptides

KW - Mixed metal complex

KW - NMR

KW - Palladium(II)

KW - Potentiometry

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M3 - Article

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JF - Journal of Inorganic Biochemistry

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