Soluble urokinase plasminogen activator receptor (suPAR) in the assessment of inflammatory activity of rheumatoid arthritis patients in remission

Gergely Toldi, G. Bekő, Gabriella Kádár, Emília MácSai, László Kovács, B. Vásárhelyi, Attila Balog

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker increasingly used for the assessment of systemic inflammation. We aimed to evaluate suPAR for the assessment of inflammatory activity in rheumatoid arthritis (RA) patients in remission. Methods: In our cross-sectional study we measured plasma suPAR and C-reactive protein (CRP) levels as well as erythrocyte sedimentation rate (ESR) in 120 RA patients at various stages of disease activity and 29 healthy age-matched controls. Results: suPAR, CRP and ESR values were higher in RA patients compared to healthy individuals. When suPAR levels were analyzed according to DAS28 scores of RA patients, suPAR level in the subgroup with DAS28≤2.6 was lower than in the subgroup with DAS28>2.6, but still higher than in controls [4.45 (3.33-5.56) ng/mL vs. 3.66 (3.10-4.67) ng/mL vs. 2.80 (2.06-3.42) ng/mL, p

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 1 2013

Fingerprint

Urokinase Plasminogen Activator Receptors
Rheumatoid Arthritis
Blood Sedimentation
Sedimentation
C-Reactive Protein
Biomarkers
Cross-Sectional Studies
Inflammation
Plasmas

Keywords

  • C-reactive protein (CRP)
  • erythrocyte sedimentation rate (ESR)
  • inflammation
  • rheumatoid arthritis
  • soluble urokinase plasminogen activator receptor (suPAR)

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Soluble urokinase plasminogen activator receptor (suPAR) in the assessment of inflammatory activity of rheumatoid arthritis patients in remission. / Toldi, Gergely; Bekő, G.; Kádár, Gabriella; MácSai, Emília; Kovács, László; Vásárhelyi, B.; Balog, Attila.

In: Clinical Chemistry and Laboratory Medicine, Vol. 51, No. 2, 01.02.2013, p. 327-332.

Research output: Contribution to journalArticle

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