Solid-state characterization of bifonazole - Beta-cyclodextrin binary systems. II

Cristina Trandafirescu, Stefana Avram, Codruta Soica, Zoltán Aigner, Gyéresi Árpád, Mihaly Kata, Cristina Dehelean, Zoltán Szabadai, Florin Borcan

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1 Citation (Scopus)


Continuing our previous researches, this paper presents the studies regarding the solid state characterization of binary systems between antimycotic bifonazole and beta-cyclodextrin. The binary systems were prepared in two (bifonazole: beta-cyclodextrin) molar ratios, 1:2 and 1:3, using the physical mixture and the kneading method. In order to characterize the solid state interaction between the two components, hot-stage microscopy, differential scanning calorimetry, X-ray diffractometry and Fourier-transformed infrared spectroscopy were used. The analysis performed indicate a molecular interaction between the components due to a partially encapsulation of bifonazole into the cyclodextrin cavity.

Original languageEnglish
Pages (from-to)1336-1339
Number of pages4
JournalRevista de Chimie
Issue number11
Publication statusPublished - Nov 1 2014


  • Beta-cyclodextrin
  • Bifonazole
  • Inclusion complex

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science (miscellaneous)
  • Engineering(all)
  • Surfaces, Coatings and Films
  • Materials Chemistry

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    Trandafirescu, C., Avram, S., Soica, C., Aigner, Z., Árpád, G., Kata, M., Dehelean, C., Szabadai, Z., & Borcan, F. (2014). Solid-state characterization of bifonazole - Beta-cyclodextrin binary systems. II. Revista de Chimie, 65(11), 1336-1339.