Solid-state characterization of bifonazole-β-cyclodextrin binary systems. Note I

Cristina Trandafirescu, Árpád Gyéresi, Zoltán Szabadai, Mihály Kata, Zoltán Aigner

Research output: Contribution to journalArticle

6 Citations (Scopus)


Antimycotic bifonazole (BIF) is a very hydrophobic compound, which is a major drawback for obtaining topical pharmaceutical formulations with optimal bioavailabiliy and for the penetration into hydrophilic human nail matrices. Cyclodextrins may increase local drug delivery by enhancing the drug release and/or permeation. The binary systems between bifonazole and β-cyclodextrin were prepared in two (BIF:β-CD) molar ratios-by physical-mixture and kneaded method. Hot-stage microscopy (HSM), differential scanning calorimetry (DSC), X-ray diffractometry and Fourier-transformed infrared spectroscopy (FT-IR) were used to characterize solid state interactions between bifonazole and β-cyclodextrin (β-CD) in their binary systems. The X-ray diffractograms, as well as the FT-IR analysis suggest the formation of a new solid phase, indicating a molecular interaction between the components. The HSM analysis and the DSC analysis sustain the hypothesis of formation of partial inclusion complexes between BIF and β-CD.

Original languageEnglish
Pages (from-to)513-523
Number of pages11
Issue number3
Publication statusPublished - 2014



  • Bifonazole
  • Inclusion complex
  • β-cyclodextrin

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Trandafirescu, C., Gyéresi, Á., Szabadai, Z., Kata, M., & Aigner, Z. (2014). Solid-state characterization of bifonazole-β-cyclodextrin binary systems. Note I. Farmacia, 62(3), 513-523.