Solid-state characterization and biological activity of betulonic acid derivatives

Ionuţ Ledeţi, Ştefana Avram, Vasile Bercean, Gabriela Vlase, Titus Vlase, Adriana Ledeţi, I. Zupkó, Marius Mioc, Lenuţa Maria Şuta, Codruţa Şoica, Cristina Dehelean

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3-2-carbamothioylhydrazonolup-20(29)-en-28-oic acid.

Original languageEnglish
Pages (from-to)22691-22702
Number of pages12
JournalMolecules
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 18 2015

Fingerprint

Hydroxylamine
activity (biology)
Bioactivity
Lead compounds
Derivatives
solid state
lead compounds
acids
Acids
Condensation
condensation
Oxidation
oxidation
Molecules
molecules
betulonic acid
pimagedine
thiosemicarbazide
betulin
n-butylamine

Keywords

  • Betulonic acid derivatives
  • Biological activity
  • MTT assay
  • Synthesis
  • Thermal analysis
  • Triterpene

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Ledeţi, I., Avram, Ş., Bercean, V., Vlase, G., Vlase, T., Ledeţi, A., ... Dehelean, C. (2015). Solid-state characterization and biological activity of betulonic acid derivatives. Molecules, 20(12), 22691-22702. https://doi.org/10.3390/molecules201219876

Solid-state characterization and biological activity of betulonic acid derivatives. / Ledeţi, Ionuţ; Avram, Ştefana; Bercean, Vasile; Vlase, Gabriela; Vlase, Titus; Ledeţi, Adriana; Zupkó, I.; Mioc, Marius; Şuta, Lenuţa Maria; Şoica, Codruţa; Dehelean, Cristina.

In: Molecules, Vol. 20, No. 12, 18.12.2015, p. 22691-22702.

Research output: Contribution to journalArticle

Ledeţi, I, Avram, Ş, Bercean, V, Vlase, G, Vlase, T, Ledeţi, A, Zupkó, I, Mioc, M, Şuta, LM, Şoica, C & Dehelean, C 2015, 'Solid-state characterization and biological activity of betulonic acid derivatives', Molecules, vol. 20, no. 12, pp. 22691-22702. https://doi.org/10.3390/molecules201219876
Ledeţi I, Avram Ş, Bercean V, Vlase G, Vlase T, Ledeţi A et al. Solid-state characterization and biological activity of betulonic acid derivatives. Molecules. 2015 Dec 18;20(12):22691-22702. https://doi.org/10.3390/molecules201219876
Ledeţi, Ionuţ ; Avram, Ştefana ; Bercean, Vasile ; Vlase, Gabriela ; Vlase, Titus ; Ledeţi, Adriana ; Zupkó, I. ; Mioc, Marius ; Şuta, Lenuţa Maria ; Şoica, Codruţa ; Dehelean, Cristina. / Solid-state characterization and biological activity of betulonic acid derivatives. In: Molecules. 2015 ; Vol. 20, No. 12. pp. 22691-22702.
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