Solid-state characterization and biological activity of betulonic acid derivatives

Ionuţ Ledeţi, Ştefana Avram, Vasile Bercean, Gabriela Vlase, Titus Vlase, Adriana Ledeţi, Istvan Zupko, Marius Mioc, Lenuţa Maria Şuta, Codruţa Şoica, Cristina Dehelean

Research output: Contribution to journalArticle

7 Citations (Scopus)


Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3-2-carbamothioylhydrazonolup-20(29)-en-28-oic acid.

Original languageEnglish
Pages (from-to)22691-22702
Number of pages12
Issue number12
Publication statusPublished - Dec 18 2015


  • Betulonic acid derivatives
  • Biological activity
  • MTT assay
  • Synthesis
  • Thermal analysis
  • Triterpene

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Ledeţi, I., Avram, Ş., Bercean, V., Vlase, G., Vlase, T., Ledeţi, A., Zupko, I., Mioc, M., Şuta, L. M., Şoica, C., & Dehelean, C. (2015). Solid-state characterization and biological activity of betulonic acid derivatives. Molecules, 20(12), 22691-22702.