Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review

Attila Zalatnai, Viktória Kis-Orha

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The solid-pseudopapillary neoplasm of the pancreas is a rare but enigmatic entity occurring mainly in young women. Since the first description by V. Frantz in 1959 the terminology of this tumor has continuously changed but it has remained simply descriptive, because the exact histogenesis is still obscure. Although in majority of cases the survival is excellent, nevertheless, the expected prognosis is not exactly predictable. In this review the authors aim to summarize its clinico-pathological features, the expected biological behavior, the molecular alterations, the immune phenotype and discuss the putative histogenesis. From diagnostic point of view, the salient histological characteristic findings are analyzed that would help to differentiate it from other, look-alike pancreatic tumors, and suggestions are made about the desirable content of the histological report.

Original languageEnglish
Pages (from-to)641-649
Number of pages9
JournalPathology and Oncology Research
Volume26
Issue number2
DOIs
Publication statusPublished - Apr 1 2020

Keywords

  • Histogenesis
  • Pancreas
  • Review
  • Solid-pseudopapillary neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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