Solid-phase synthesis of glycopeptides: synthesis of Nα-Flourenylmethoxycarbonyl L-asparagine Nβ-glycosides

Laszlo Urge, Emma Kollat, Miklos Hollosi, Ilona Laczko, Krzysztof Wroblewski, Jan Thurin, Laszlo Otvos

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Abstract

It was found that crude 1-glycosylamines, prepared with saturated aqueous NH4HCO3 from reducing sugars, can be coupled with Fmoc-Asp(OPfp)-OtBu in N,N-dimethylformamide-water mixtures. Purification and removal of the tBu group results in Nβ- glycosides of Fmoc-Asn-OH which can be used for the solid phase synthesis of glycopeptides.

Original languageEnglish
Pages (from-to)3445-3448
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number29
DOIs
Publication statusPublished - Jul 15 1991

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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