Solid-phase synthesis of glycopeptides: synthesis of Nα-Flourenylmethoxycarbonyl L-asparagine Nβ-glycosides

Laszlo Urge, Emma Kollat, Miklos Hollosi, Ilona Laczko, Krzysztof Wroblewski, Jan Thurin, Laszlo Otvos

Research output: Contribution to journalArticle

45 Citations (Scopus)


It was found that crude 1-glycosylamines, prepared with saturated aqueous NH4HCO3 from reducing sugars, can be coupled with Fmoc-Asp(OPfp)-OtBu in N,N-dimethylformamide-water mixtures. Purification and removal of the tBu group results in Nβ- glycosides of Fmoc-Asn-OH which can be used for the solid phase synthesis of glycopeptides.

Original languageEnglish
Pages (from-to)3445-3448
Number of pages4
JournalTetrahedron Letters
Issue number29
Publication statusPublished - Jul 15 1991


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this