Solid phase synthesis of a GHRP analog containing C-terminal thioamide group

Zs Majer, M. Zewdu, M. Hollósi, J. Seprodi, Zs Vadász, I. Teplán

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

[Lyst6]GHRP, the C-terminally thionated analog of the highly potent growth hormone releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 was prepared by using solid support. The success of the synthesis showed that Lawesson's reagent can be used for selective thionation of an amide group not only in solution but also on the surface of a resin. The C-terminal thioamide group proved to be stable under the conditions of the solid phase synthesis.

Original languageEnglish
Pages (from-to)1017-1020
Number of pages4
JournalBiochemical and biophysical research communications
Volume150
Issue number3
DOIs
Publication statusPublished - Feb 15 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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