Solid-liquid phase alkylation of n-heterocycles: Microwave-assisted synthesis as an environmentally friendly alternative

Mátyás Milen, Alajos Grün, Erika Bálint, András Dancsó, György Keglevich

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23 Citations (Scopus)

Abstract

The solid-liquid phase alkylation of a variety of five-membered N-heterocycles (carbazole, imidazole, benzimidazole, and indole-3-carbaldehyde) was carried out under different conditions. The use of alkali carbonate in dimethylformamide or in MeCN (in the latter case, in the presence of a phase-transfer catalyst) is a suitable method to prepare the corresponding N-alkylated products in an efficient way. In most cases, the solventless, microwave-assisted reaction is an environmentally friendly alternative to traditional methods. Copyrigh

Original languageEnglish
Pages (from-to)2291-2301
Number of pages11
JournalSynthetic Communications
Volume40
Issue number15
DOIs
Publication statusPublished - Jul 16 2010

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Keywords

  • N-Alkylation
  • N-heterocycles
  • microwave synthesis
  • phase-transfer catalysis
  • solid-liquid phase

ASJC Scopus subject areas

  • Organic Chemistry

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