Solation of chelidonine as an analgesic compound from Chelidonium majus L.

Gülçin Saltan Çitoǧlu, Hanefi Özbek, Özlem Bahadir Acikara, Eszter Baitz Gacs

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3 Citations (Scopus)

Abstract

In this study the analgesic activity of chelidonine which was isolated from the aerial parts of Chelidonium majus (Papaveraceae), was investigated by using tail-flick test. Chelidonine is one of the main alkaloid in the aerial parts of C. majus. Isolation of chelidonine was performed by using chromatographic techniques. Spectroscopic ( 1H-NMR, 13C-NMR) and physical (melting point) methods were used for structure elucidation of the isolated compound. Analgesic activity of the compound was evaluated by using tail-flick test on mice at 5 mg/kg dose. Chelidonine produced higher analgesic activity than aspirine at 90 th minute. However equivalent analgesic activity to aspirine was observed at 150 th minute with chelidonine treatment.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalAnkara Universitesi Eczacilik Fakultesi Dergisi
Volume38
Issue number1
Publication statusPublished - Dec 1 2009

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Keywords

  • Analgesic activity
  • Chelidonine
  • Chelidonium majus
  • Papaveraceae
  • Tail-flick test

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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