Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer's disease patients' brain regions

A. Járdánházy, T. Járdánházy, J. Kálmán

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Bilateral temporo-parietal hypoperfusion and decreased glucose metabolism are characteristic in vivo findings in Alzheimer's disease (AD). Lactate is a metabolic vasodilator and is known to induce increased cerebral blood flow in healthy adults. The present study addresses the issue whether sodium lactate infusion affects functional state and resulting electroencephalographic patterns of AD patients. Twelve late-onset sporadic AD probands participated in this self-control study. The relative power and synchronization likelihood (SL) values of the electroencephalographic samples were calculated and compared off-line before and after sodium lactate infusion (0.5 m, 5 ml/kg body weight). Based on the reactivity to sodium lactate the scalp could be divided into three parts; no significant changes were seen in the seriously damaged (P3-P4) areas. The moderately affected regions in the close neighborhood showed a paradoxic inactivation with electroencephalographic slowing, a likely consequence of the metabolic-like steal effect of the near-normal areas outside. These results indicate a diminished vascular and/or metabolic reserve capacity to sodium lactate challenge in AD and confirm the formerly described electroencephalographic abnormalities.

Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalEuropean Journal of Neurology
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Sodium Lactate
Electroencephalography
Alzheimer Disease
Brain
Cerebrovascular Circulation
Scalp
Vasodilator Agents
Blood Vessels
Lactic Acid
Body Weight
Glucose
Power (Psychology)

Keywords

  • Alzheimer's disease
  • Metabolic and vascular reactivity
  • Quantitative EEG
  • Sodium lactate
  • Synchronization likelihood

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer's disease patients' brain regions. / Járdánházy, A.; Járdánházy, T.; Kálmán, J.

In: European Journal of Neurology, Vol. 15, No. 2, 02.2008, p. 150-155.

Research output: Contribution to journalArticle

@article{302ddf3aba3d43ae8f6ebffda306fcab,
title = "Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer's disease patients' brain regions",
abstract = "Bilateral temporo-parietal hypoperfusion and decreased glucose metabolism are characteristic in vivo findings in Alzheimer's disease (AD). Lactate is a metabolic vasodilator and is known to induce increased cerebral blood flow in healthy adults. The present study addresses the issue whether sodium lactate infusion affects functional state and resulting electroencephalographic patterns of AD patients. Twelve late-onset sporadic AD probands participated in this self-control study. The relative power and synchronization likelihood (SL) values of the electroencephalographic samples were calculated and compared off-line before and after sodium lactate infusion (0.5 m, 5 ml/kg body weight). Based on the reactivity to sodium lactate the scalp could be divided into three parts; no significant changes were seen in the seriously damaged (P3-P4) areas. The moderately affected regions in the close neighborhood showed a paradoxic inactivation with electroencephalographic slowing, a likely consequence of the metabolic-like steal effect of the near-normal areas outside. These results indicate a diminished vascular and/or metabolic reserve capacity to sodium lactate challenge in AD and confirm the formerly described electroencephalographic abnormalities.",
keywords = "Alzheimer's disease, Metabolic and vascular reactivity, Quantitative EEG, Sodium lactate, Synchronization likelihood",
author = "A. J{\'a}rd{\'a}nh{\'a}zy and T. J{\'a}rd{\'a}nh{\'a}zy and J. K{\'a}lm{\'a}n",
year = "2008",
month = "2",
doi = "10.1111/j.1468-1331.2007.02016.x",
language = "English",
volume = "15",
pages = "150--155",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer's disease patients' brain regions

AU - Járdánházy, A.

AU - Járdánházy, T.

AU - Kálmán, J.

PY - 2008/2

Y1 - 2008/2

N2 - Bilateral temporo-parietal hypoperfusion and decreased glucose metabolism are characteristic in vivo findings in Alzheimer's disease (AD). Lactate is a metabolic vasodilator and is known to induce increased cerebral blood flow in healthy adults. The present study addresses the issue whether sodium lactate infusion affects functional state and resulting electroencephalographic patterns of AD patients. Twelve late-onset sporadic AD probands participated in this self-control study. The relative power and synchronization likelihood (SL) values of the electroencephalographic samples were calculated and compared off-line before and after sodium lactate infusion (0.5 m, 5 ml/kg body weight). Based on the reactivity to sodium lactate the scalp could be divided into three parts; no significant changes were seen in the seriously damaged (P3-P4) areas. The moderately affected regions in the close neighborhood showed a paradoxic inactivation with electroencephalographic slowing, a likely consequence of the metabolic-like steal effect of the near-normal areas outside. These results indicate a diminished vascular and/or metabolic reserve capacity to sodium lactate challenge in AD and confirm the formerly described electroencephalographic abnormalities.

AB - Bilateral temporo-parietal hypoperfusion and decreased glucose metabolism are characteristic in vivo findings in Alzheimer's disease (AD). Lactate is a metabolic vasodilator and is known to induce increased cerebral blood flow in healthy adults. The present study addresses the issue whether sodium lactate infusion affects functional state and resulting electroencephalographic patterns of AD patients. Twelve late-onset sporadic AD probands participated in this self-control study. The relative power and synchronization likelihood (SL) values of the electroencephalographic samples were calculated and compared off-line before and after sodium lactate infusion (0.5 m, 5 ml/kg body weight). Based on the reactivity to sodium lactate the scalp could be divided into three parts; no significant changes were seen in the seriously damaged (P3-P4) areas. The moderately affected regions in the close neighborhood showed a paradoxic inactivation with electroencephalographic slowing, a likely consequence of the metabolic-like steal effect of the near-normal areas outside. These results indicate a diminished vascular and/or metabolic reserve capacity to sodium lactate challenge in AD and confirm the formerly described electroencephalographic abnormalities.

KW - Alzheimer's disease

KW - Metabolic and vascular reactivity

KW - Quantitative EEG

KW - Sodium lactate

KW - Synchronization likelihood

UR - http://www.scopus.com/inward/record.url?scp=38349186381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38349186381&partnerID=8YFLogxK

U2 - 10.1111/j.1468-1331.2007.02016.x

DO - 10.1111/j.1468-1331.2007.02016.x

M3 - Article

C2 - 18093154

AN - SCOPUS:38349186381

VL - 15

SP - 150

EP - 155

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 2

ER -