Sodium calcium exchange as a target for antiarrhythmic therapy

K. R. Sipido, A. Varró, D. Eisner

Research output: Chapter in Book/Report/Conference proceedingChapter

39 Citations (Scopus)

Abstract

In search of better antiarrhythmic therapy, targeting the Na/Ca exchanger is an option to be explored. The rationale is that increased activity of the Na/Ca exchanger has been implicated in arrhythmogenesis in a number of conditions. The evidence is strong for triggered arrhythmias related to Ca 2+ overload, due to increased Na+ load or during adrenergic stimulation; the Na/Ca exchanger may be important in triggered arrhythmias in heart failure and in atrial fibrillation. There is also evidence for a less direct role of the Na/Ca exchanger in contributing to remodelling processes. In this chapter, we review this evidence and discuss the consequences of inhibition of Na/Ca exchange in the perspective of its physiological role in Ca2+ homeostasis. We summarize the current data on the use of available blockers of Na/Ca exchange and propose a framework for further study and development of such drugs. Very selective agents have great potential as tools for further study of the role the Na/Ca exchanger plays in arrhythmogenesis. For therapy, they may have their specific indications, but they carry the risk of increasing Ca2+ load of the cell. Agentswith a broader action that includes Ca2+ channel blockmay have advantages in other conditions, e.g. with Ca2+ overload. Additional actions such as block of K+ channels, which may be unwanted in e.g. heart failure, may be used to advantage as well.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
Pages159-199
Number of pages41
Volume171
DOIs
Publication statusPublished - 2006

Publication series

NameHandbook of Experimental Pharmacology
Volume171
ISSN (Print)01712004
ISSN (Electronic)18650325

Fingerprint

Cardiac Arrhythmias
Heart Failure
Sodium
Calcium
Adrenergic Agents
Atrial Fibrillation
Homeostasis
Therapeutics
Pharmaceutical Preparations

Keywords

  • Afterdepolarizations
  • Arrhythmias
  • Heart failure
  • Sarcoplasmic reticulum
  • Sodium/calcium exchange

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry

Cite this

Sipido, K. R., Varró, A., & Eisner, D. (2006). Sodium calcium exchange as a target for antiarrhythmic therapy. In Handbook of Experimental Pharmacology (Vol. 171, pp. 159-199). (Handbook of Experimental Pharmacology; Vol. 171). https://doi.org/10.1007/3-540-29715-4-6

Sodium calcium exchange as a target for antiarrhythmic therapy. / Sipido, K. R.; Varró, A.; Eisner, D.

Handbook of Experimental Pharmacology. Vol. 171 2006. p. 159-199 (Handbook of Experimental Pharmacology; Vol. 171).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sipido, KR, Varró, A & Eisner, D 2006, Sodium calcium exchange as a target for antiarrhythmic therapy. in Handbook of Experimental Pharmacology. vol. 171, Handbook of Experimental Pharmacology, vol. 171, pp. 159-199. https://doi.org/10.1007/3-540-29715-4-6
Sipido KR, Varró A, Eisner D. Sodium calcium exchange as a target for antiarrhythmic therapy. In Handbook of Experimental Pharmacology. Vol. 171. 2006. p. 159-199. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/3-540-29715-4-6
Sipido, K. R. ; Varró, A. ; Eisner, D. / Sodium calcium exchange as a target for antiarrhythmic therapy. Handbook of Experimental Pharmacology. Vol. 171 2006. pp. 159-199 (Handbook of Experimental Pharmacology).
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