Sodium azide treatment decreases striatal and cortical concentrations of α-tocopherol in rats

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Sodium azide (20 mg/kgsc), given for a maximum of 3 days to rats, significantly decreased the α-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36% (statistically not significant) elevation on day 3. Reduced glutathione levels were not altered. The observations suggest an important role for α-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalJournal of Neural Transmission
Volume108
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Corpus Striatum
Sodium Azide
Tocopherols
Glutathione Disulfide
Azides
Lipid Peroxides
Free Radicals
Glutathione
Brain

Keywords

  • α-tocopherol
  • Cortex
  • Glutathione
  • Sodium azide
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{2137b21c0a7c4183bc5a5ebeb234c08d,
title = "Sodium azide treatment decreases striatal and cortical concentrations of α-tocopherol in rats",
abstract = "Sodium azide (20 mg/kgsc), given for a maximum of 3 days to rats, significantly decreased the α-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36{\%} (statistically not significant) elevation on day 3. Reduced glutathione levels were not altered. The observations suggest an important role for α-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals.",
keywords = "α-tocopherol, Cortex, Glutathione, Sodium azide, Striatum",
author = "L. V{\'e}csei and J. Tajti and P. Kliv{\'e}nyi and S. Pint{\'e}r and E. Karg",
year = "2001",
doi = "10.1007/s007020170072",
language = "English",
volume = "108",
pages = "273--278",
journal = "Journal of Neural Transmission",
issn = "0300-9564",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Sodium azide treatment decreases striatal and cortical concentrations of α-tocopherol in rats

AU - Vécsei, L.

AU - Tajti, J.

AU - Klivényi, P.

AU - Pintér, S.

AU - Karg, E.

PY - 2001

Y1 - 2001

N2 - Sodium azide (20 mg/kgsc), given for a maximum of 3 days to rats, significantly decreased the α-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36% (statistically not significant) elevation on day 3. Reduced glutathione levels were not altered. The observations suggest an important role for α-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals.

AB - Sodium azide (20 mg/kgsc), given for a maximum of 3 days to rats, significantly decreased the α-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36% (statistically not significant) elevation on day 3. Reduced glutathione levels were not altered. The observations suggest an important role for α-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals.

KW - α-tocopherol

KW - Cortex

KW - Glutathione

KW - Sodium azide

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=0034895489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034895489&partnerID=8YFLogxK

U2 - 10.1007/s007020170072

DO - 10.1007/s007020170072

M3 - Article

C2 - 11341478

AN - SCOPUS:0034895489

VL - 108

SP - 273

EP - 278

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

IS - 3

ER -