SNAP-25: A novel candidate gene in psychiatric genetics

Réka Kovács-Nagy, Jimmy Hu, Z. Rónai, M. Sasvári

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

SNAP-25 (synaptosomal-associated protein of 25 kDa) is an integral part of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor), a docking complex for synaptic vesicle exocytosis and neurotransmitter release. Result with SNAP-25 deficient mouse models highly accelerated association studies of SNAP-25 as a candidate gene for psychiatric disorders, such as Attention Deficit Hyperactivity Disorder (ADHD) and Schizophrenia. Candidate gene studies implicate a large number of single nucleotide polymorphism (SNPs). Among the numerous SNPs, the miR SNPs are novel functional variants affecting the binding of specific microRNA to their target mRNA. According to our in silico studies there are two putative miR SNPs in the 3'untranslated region (3'UTR) of the SNAP-25 gene. If the putative miR SNPs are shown to have a function in vivo their implication in further psychogenetic association studies will have a higher impact.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalNeuropsychopharmacologia Hungarica
Volume11
Issue number2
Publication statusPublished - 2009

Fingerprint

Synaptosomal-Associated Protein 25
Single Nucleotide Polymorphism
Psychiatry
SNARE Proteins
Genes
Behavioral Genetics
Synaptic Vesicles
Exocytosis
3' Untranslated Regions
Attention Deficit Disorder with Hyperactivity
MicroRNAs
Computer Simulation
Neurotransmitter Agents
Schizophrenia
Messenger RNA

Keywords

  • ADHD
  • Candidate gene study
  • Depression
  • microRNA
  • Psychiatric genetics
  • SNAP-25

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

SNAP-25 : A novel candidate gene in psychiatric genetics. / Kovács-Nagy, Réka; Hu, Jimmy; Rónai, Z.; Sasvári, M.

In: Neuropsychopharmacologia Hungarica, Vol. 11, No. 2, 2009, p. 89-94.

Research output: Contribution to journalArticle

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