Smooth muscle-depressant activity of AP-18, a putative TRPA1 antagonist in the guinea pig intestine

L. Barthó, Zsolt Sándor, Dezsö Kelemen, Robert Papp, R. Benkó

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

AP-18, a putative antagonist at TRPA1 receptor/ion channel, caused smooth muscle relaxation at 10-100 μmol/l. It inhibited cholinergic twitch responses evoked by electrical field stimulation of cholinergic nerves as well as contractions in response to acetylcholine and histamine in the guinea pig small intestine. AP-18 (30 μmol/l) blocked spontaneous contractions of longitudinal strips of human jejunum. It is concluded that AP-18 may have limited value in studying TRPA1-mediated responses in smooth muscles and should probably be used with care in other preparations because of possible nonspecific effects.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalPharmacology
Volume94
Issue number3-4
DOIs
Publication statusPublished - Apr 20 2014

Fingerprint

Cholinergic Agents
Intestines
Smooth Muscle
Guinea Pigs
Muscle Relaxation
Jejunum
Ion Channels
Histamine
Electric Stimulation
Acetylcholine
Small Intestine

Keywords

  • Acetylcholine
  • AP-18
  • Cholinergic twitch
  • Guinea pig intestine
  • Histamine
  • Human jejunum
  • Nonspecific inhibition
  • Smooth muscle

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Smooth muscle-depressant activity of AP-18, a putative TRPA1 antagonist in the guinea pig intestine. / Barthó, L.; Sándor, Zsolt; Kelemen, Dezsö; Papp, Robert; Benkó, R.

In: Pharmacology, Vol. 94, No. 3-4, 20.04.2014, p. 131-134.

Research output: Contribution to journalArticle

Barthó, L. ; Sándor, Zsolt ; Kelemen, Dezsö ; Papp, Robert ; Benkó, R. / Smooth muscle-depressant activity of AP-18, a putative TRPA1 antagonist in the guinea pig intestine. In: Pharmacology. 2014 ; Vol. 94, No. 3-4. pp. 131-134.
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