Smooth muscle-depressant activity of AP-18, a putative TRPA1 antagonist in the guinea pig intestine

Lorand Bartho, Zsolt Sándor, Dezsö Kelemen, Robert Papp, Rita Benko

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

AP-18, a putative antagonist at TRPA1 receptor/ion channel, caused smooth muscle relaxation at 10-100 μmol/l. It inhibited cholinergic twitch responses evoked by electrical field stimulation of cholinergic nerves as well as contractions in response to acetylcholine and histamine in the guinea pig small intestine. AP-18 (30 μmol/l) blocked spontaneous contractions of longitudinal strips of human jejunum. It is concluded that AP-18 may have limited value in studying TRPA1-mediated responses in smooth muscles and should probably be used with care in other preparations because of possible nonspecific effects.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalPharmacology
Volume94
Issue number3-4
DOIs
Publication statusPublished - Apr 20 2014

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Keywords

  • AP-18
  • Acetylcholine
  • Cholinergic twitch
  • Guinea pig intestine
  • Histamine
  • Human jejunum
  • Nonspecific inhibition
  • Smooth muscle

ASJC Scopus subject areas

  • Pharmacology

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