Smooth muscle cells and elastic fiber genesis

H. Jellinek, A. Kádár

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Activated smooth muscle cells show many signs of increased metabolic activity. The marked endoplasmic reticulum suggests the synthesis of exportable proteins and probably of connective tissue proteins. As the smooth muscle cells are of mesenchymal origin, a latent connective tissue fiber synthesizing capacity may well be supposed. There is reason to believe that the aortic smooth muscle cells, originating from multipotent mesenchymal cells, are capable of synthesizing the precursors of elastin and ground substances. The authors believe that the smooth muscle cells synthesize desmosin and isodesmosin, as well as the amorphous proteoglycans required for the formation of the elastic aggregations and the glycosaminoglycan components of the microfilaments. The excretion or transport of elastin and glycosaminoglycans into the extracellular space takes place either directly through vesicles via the endoplasmic reticulum, or indirectly through the Golgi complex, partly in the form of protein polysaccharides. The further organization of the fibers then takes place in the extracellular space.

Original languageEnglish
Pages (from-to)257-265
Number of pages9
JournalMorphologiai es igazsagugyi orvosi szemle
Volume13
Issue number4
Publication statusPublished - 1973

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Elastic Tissue
Smooth Muscle Myocytes
Elastin
Extracellular Space
Glycosaminoglycans
Endoplasmic Reticulum
Connective Tissue
Proteins
Golgi Apparatus
Proteoglycans
Actin Cytoskeleton
Polysaccharides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Smooth muscle cells and elastic fiber genesis. / Jellinek, H.; Kádár, A.

In: Morphologiai es igazsagugyi orvosi szemle, Vol. 13, No. 4, 1973, p. 257-265.

Research output: Contribution to journalArticle

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