Smoking, nicotine and neuropsychiatric disorders

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Tobacco smoking is an extremely addictive and harmful form of nicotine (NIC) consumption, but unfortunately also the most prevalent. Although disproportionately high frequencies of smoking and its health consequences among psychiatric patients are widely known, the neurobiological background of this epidemiological association is still obscure. The diverse neuroactive effects of NIC and some other major tobacco smoke constituents in the central nervous system may underlie this association. This present paper summarizes the pharmacology of NIC and its receptors (nAChR) based on a systematic review of the literature. The role of the brain's reward system(s) in NIC addiction and the results of functional and structural neuroimaging studies on smoking-related states and behaviors (i.e. dependence, craving, withdrawal) are also discussed. In addition, the epidemiological, neurobiological, and genetic aspects of smoking in several specific neuropsychiatric disorders are reviewed and the clinical relevance of smoking in these disease states addressed.

Original languageEnglish
Pages (from-to)295-342
Number of pages48
JournalNeuroscience and Biobehavioral Reviews
Volume34
Issue number3
DOIs
Publication statusPublished - Feb 2010

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Nicotine
Smoking
Functional Neuroimaging
Reward
Smoke
Tobacco
Psychiatry
Central Nervous System
Pharmacology
Health
Brain

Keywords

  • ADHD
  • Alzheimer's disease
  • Mood disorders
  • Nicotine
  • Nicotinic acetylcholine receptors
  • Parkinson's disease
  • Schizophrenia
  • Smoking
  • Suicide

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Smoking, nicotine and neuropsychiatric disorders. / Döme, P.; Lazáry, J.; Kalapos, M.; Ríhmer, Z.

In: Neuroscience and Biobehavioral Reviews, Vol. 34, No. 3, 02.2010, p. 295-342.

Research output: Contribution to journalArticle

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