Small Peptides Derived from Penetratin as Antibacterial Agents

Oscar Parravicini, C. Somlai, Sebastián A. Andujar, Adriana D. Garro, Beatriz Lima, Alejandro Tapia, Gabriela Feresin, A. Perczel, G. Tóth, Javier López Cascales, Ana M. Rodríguez, Ricardo D. Enriz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The synthesis, in vitro evaluation and conformational study of several small-size peptides acting as antibacterial agents are reported. Among the compounds evaluated, the peptides Arg-Gln-Ile-Lys-Ile-Trp-Arg-Arg-Met-Lys-Trp-Lys-Lys-NH2, Arg-Gln-Ile-Lys-Ile-Arg-Arg-Met-Lys-Trp-Arg-NH2, and Arg-Gln-Ile-Trp-Trp-Trp-Trp-Gln-Arg-NH2 exhibited significant antibacterial activity. These were found to be very active antibacterial compounds, considering their small molecular size. In order to better understand the antibacterial activity obtained for these peptides, an exhaustive conformational analysis was performed, using both theoretical calculations and experimental measurements. Molecular dynamics simulations using two different media (water and trifluoroethanol/water) were employed. The results of these theoretical calculations were corroborated by experimental circular dichroism measurements. A brief discussion on the possible mechanism of action of these peptides at molecular level is also presented. Some of the peptides reported here constitute very interesting structures to be used as starting compounds for the design of new small-size peptides possessing antibacterial activity.

Original languageEnglish
JournalArchiv der Pharmazie
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Anti-Bacterial Agents
Peptides
Trifluoroethanol
Water
Molecular Dynamics Simulation
Circular Dichroism
penetratin
argininamide

Keywords

  • Antibacterial activity
  • Peptide syntheses
  • Rational drug design

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

Cite this

Parravicini, O., Somlai, C., Andujar, S. A., Garro, A. D., Lima, B., Tapia, A., ... Enriz, R. D. (Accepted/In press). Small Peptides Derived from Penetratin as Antibacterial Agents. Archiv der Pharmazie. https://doi.org/10.1002/ardp.201500419

Small Peptides Derived from Penetratin as Antibacterial Agents. / Parravicini, Oscar; Somlai, C.; Andujar, Sebastián A.; Garro, Adriana D.; Lima, Beatriz; Tapia, Alejandro; Feresin, Gabriela; Perczel, A.; Tóth, G.; Cascales, Javier López; Rodríguez, Ana M.; Enriz, Ricardo D.

In: Archiv der Pharmazie, 2016.

Research output: Contribution to journalArticle

Parravicini, O, Somlai, C, Andujar, SA, Garro, AD, Lima, B, Tapia, A, Feresin, G, Perczel, A, Tóth, G, Cascales, JL, Rodríguez, AM & Enriz, RD 2016, 'Small Peptides Derived from Penetratin as Antibacterial Agents', Archiv der Pharmazie. https://doi.org/10.1002/ardp.201500419
Parravicini, Oscar ; Somlai, C. ; Andujar, Sebastián A. ; Garro, Adriana D. ; Lima, Beatriz ; Tapia, Alejandro ; Feresin, Gabriela ; Perczel, A. ; Tóth, G. ; Cascales, Javier López ; Rodríguez, Ana M. ; Enriz, Ricardo D. / Small Peptides Derived from Penetratin as Antibacterial Agents. In: Archiv der Pharmazie. 2016.
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