Small G proteins and their regulators in cellular signalling

Roland Csépányi-Kömi, Magdolna Lévay, Erzsébet Ligeti

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Small molecular weight GTPases (small G proteins) are essential in the transduction of signals from different plasma membrane receptors. Due to their endogenous GTP-hydrolyzing activity, these proteins function as time-dependent biological switches controlling diverse cellular functions including cell shape and migration, cell proliferation, gene transcription, vesicular transport and membrane-trafficking. This review focuses on endocrine diseases linked to small G proteins. We provide examples for the regulation of the activity of small G proteins by various mechanisms such as posttranslational modifications, guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs) or guanine nucleotide dissociation inhibitors (GDIs). Finally we summarize endocrine diseases where small G proteins or their regulatory proteins have been revealed as the cause.

Original languageEnglish
Pages (from-to)10-20
Number of pages11
JournalMolecular and Cellular Endocrinology
Volume353
Issue number1-2
DOIs
Publication statusPublished - Apr 28 2012

Keywords

  • Endocrine diseases
  • GTPase activating proteins (GAPs)
  • Guanine nucleotide dissociation inhibitors (GDIs)
  • Guanine nucleotide exchange factors (GEFs)
  • Prenylation
  • Small G proteins (smg)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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