Slow delayed rectifier potassium current (IKs) and the repolarization reserve

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60 Citations (Scopus)

Abstract

The aim of this review is to present the properties of the slow component of the delayed rectifier potassium current (IKs) in the human ventricle. The review gives a detailed description of the physiology, molecular biology and pharmacology of the IKs current, including kinetic properties, genetic structures, agonists and antagonists. The authors also present the role of the IKs current in the human cardiac repolarization focusing on several pathophysiological situations, such as the LQT syndrome and the Torsade de Pointes arrhythmia.

Original languageEnglish
Pages (from-to)64-78
Number of pages15
JournalAnnals of Noninvasive Electrocardiology
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2007

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Potassium
Torsades de Pointes
Genetic Structures
Cardiac Arrhythmias
Molecular Biology
Pharmacology

Keywords

  • Arrhythmias
  • Cardiac action potential
  • I
  • K current
  • Long-QT syndrome
  • Repolarization reserve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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AB - The aim of this review is to present the properties of the slow component of the delayed rectifier potassium current (IKs) in the human ventricle. The review gives a detailed description of the physiology, molecular biology and pharmacology of the IKs current, including kinetic properties, genetic structures, agonists and antagonists. The authors also present the role of the IKs current in the human cardiac repolarization focusing on several pathophysiological situations, such as the LQT syndrome and the Torsade de Pointes arrhythmia.

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