Slight decrease in bone mineralization in cow milk-sensitive children

Edit Hidvégi, A. Arató, Endre Cserháti, C. Horváth, András Szabó, A. Szabó

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Patients with cow milk allergy (CMA) are potentially at risk for osteopenia because their milk-free diet usually contains a low calcium content. In our study, different parameters of bone mineralization in children with CMA were investigated. Patients and Methods: Twenty-seven CMA patients (mean age, 4.3 years; range, 3-8 years) were enrolled in the study. During a mean milk-free diet period of 11.8 months, children were fed extensively hydrolyzed or soy-based formulas. After a milk challenge test, 7 patients showed allergic symptoms, and the other 20 children had transient CMA. From the sera of all patients, the levels of sodium, potassium, chloride, calcium, phosphate, and magnesium ions, as well as alkaline phosphatase (AP), parathyroid hormone (PTH), osteocalcin, and beta-crosslaps, were determined. These values were compared with those of 20 healthy age-matched controls. Bone mineral density was measured as well. Results: The AP and PTH concentrations were higher in CMA patients than in the control group (AP: 610.2 U/L vs. 499.7 U/L, P <0.01; PTH: 1.56 pmol/L vs. 0.83 pmol/L, P <0.03), but all values were in the normal range. The osteocalcin concentration was similar in both groups, and the beta-crosslaps concentration was lower in CMA patients than in controls (0.92 vs. 1.47 ng/mL, P <0.001). The mean Z score of bone mineral density in patients with CMA was -0.6. In 10 cases, the Z score was less than the -1 SD value. On the basis of the Z score, CMA patients were divided into two groups. The PTH concentration was significantly elevated in the group with lower Z score (2.24 pmol/L vs. 1.16 pmol/L; P <0.03). Conclusion: The results suggest that, in children with CMA who are on a cow milk-free diet, slight disturbances of bone mineralization can be observed by osteodensitometry.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 2003

Fingerprint

Milk Hypersensitivity
Physiologic Calcification
bone mineralization
milk allergy
Milk
milk
glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine
Parathyroid Hormone
parathyroid hormone
Alkaline Phosphatase
Osteocalcin
Diet
alkaline phosphatase
Bone Density
osteocalcin
bone density
Potassium Chloride
Metabolic Bone Diseases
diet
osteopenia

Keywords

  • Bone mineralization
  • Child
  • Cow milk allergy

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Slight decrease in bone mineralization in cow milk-sensitive children. / Hidvégi, Edit; Arató, A.; Cserháti, Endre; Horváth, C.; Szabó, András; Szabó, A.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 36, No. 1, 01.2003, p. 44-49.

Research output: Contribution to journalArticle

@article{cfe97ea136864d7f88cae7ff5faf9ab4,
title = "Slight decrease in bone mineralization in cow milk-sensitive children",
abstract = "Background: Patients with cow milk allergy (CMA) are potentially at risk for osteopenia because their milk-free diet usually contains a low calcium content. In our study, different parameters of bone mineralization in children with CMA were investigated. Patients and Methods: Twenty-seven CMA patients (mean age, 4.3 years; range, 3-8 years) were enrolled in the study. During a mean milk-free diet period of 11.8 months, children were fed extensively hydrolyzed or soy-based formulas. After a milk challenge test, 7 patients showed allergic symptoms, and the other 20 children had transient CMA. From the sera of all patients, the levels of sodium, potassium, chloride, calcium, phosphate, and magnesium ions, as well as alkaline phosphatase (AP), parathyroid hormone (PTH), osteocalcin, and beta-crosslaps, were determined. These values were compared with those of 20 healthy age-matched controls. Bone mineral density was measured as well. Results: The AP and PTH concentrations were higher in CMA patients than in the control group (AP: 610.2 U/L vs. 499.7 U/L, P <0.01; PTH: 1.56 pmol/L vs. 0.83 pmol/L, P <0.03), but all values were in the normal range. The osteocalcin concentration was similar in both groups, and the beta-crosslaps concentration was lower in CMA patients than in controls (0.92 vs. 1.47 ng/mL, P <0.001). The mean Z score of bone mineral density in patients with CMA was -0.6. In 10 cases, the Z score was less than the -1 SD value. On the basis of the Z score, CMA patients were divided into two groups. The PTH concentration was significantly elevated in the group with lower Z score (2.24 pmol/L vs. 1.16 pmol/L; P <0.03). Conclusion: The results suggest that, in children with CMA who are on a cow milk-free diet, slight disturbances of bone mineralization can be observed by osteodensitometry.",
keywords = "Bone mineralization, Child, Cow milk allergy",
author = "Edit Hidv{\'e}gi and A. Arat{\'o} and Endre Cserh{\'a}ti and C. Horv{\'a}th and Andr{\'a}s Szab{\'o} and A. Szab{\'o}",
year = "2003",
month = "1",
doi = "10.1097/00005176-200301000-00010",
language = "English",
volume = "36",
pages = "44--49",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Slight decrease in bone mineralization in cow milk-sensitive children

AU - Hidvégi, Edit

AU - Arató, A.

AU - Cserháti, Endre

AU - Horváth, C.

AU - Szabó, András

AU - Szabó, A.

PY - 2003/1

Y1 - 2003/1

N2 - Background: Patients with cow milk allergy (CMA) are potentially at risk for osteopenia because their milk-free diet usually contains a low calcium content. In our study, different parameters of bone mineralization in children with CMA were investigated. Patients and Methods: Twenty-seven CMA patients (mean age, 4.3 years; range, 3-8 years) were enrolled in the study. During a mean milk-free diet period of 11.8 months, children were fed extensively hydrolyzed or soy-based formulas. After a milk challenge test, 7 patients showed allergic symptoms, and the other 20 children had transient CMA. From the sera of all patients, the levels of sodium, potassium, chloride, calcium, phosphate, and magnesium ions, as well as alkaline phosphatase (AP), parathyroid hormone (PTH), osteocalcin, and beta-crosslaps, were determined. These values were compared with those of 20 healthy age-matched controls. Bone mineral density was measured as well. Results: The AP and PTH concentrations were higher in CMA patients than in the control group (AP: 610.2 U/L vs. 499.7 U/L, P <0.01; PTH: 1.56 pmol/L vs. 0.83 pmol/L, P <0.03), but all values were in the normal range. The osteocalcin concentration was similar in both groups, and the beta-crosslaps concentration was lower in CMA patients than in controls (0.92 vs. 1.47 ng/mL, P <0.001). The mean Z score of bone mineral density in patients with CMA was -0.6. In 10 cases, the Z score was less than the -1 SD value. On the basis of the Z score, CMA patients were divided into two groups. The PTH concentration was significantly elevated in the group with lower Z score (2.24 pmol/L vs. 1.16 pmol/L; P <0.03). Conclusion: The results suggest that, in children with CMA who are on a cow milk-free diet, slight disturbances of bone mineralization can be observed by osteodensitometry.

AB - Background: Patients with cow milk allergy (CMA) are potentially at risk for osteopenia because their milk-free diet usually contains a low calcium content. In our study, different parameters of bone mineralization in children with CMA were investigated. Patients and Methods: Twenty-seven CMA patients (mean age, 4.3 years; range, 3-8 years) were enrolled in the study. During a mean milk-free diet period of 11.8 months, children were fed extensively hydrolyzed or soy-based formulas. After a milk challenge test, 7 patients showed allergic symptoms, and the other 20 children had transient CMA. From the sera of all patients, the levels of sodium, potassium, chloride, calcium, phosphate, and magnesium ions, as well as alkaline phosphatase (AP), parathyroid hormone (PTH), osteocalcin, and beta-crosslaps, were determined. These values were compared with those of 20 healthy age-matched controls. Bone mineral density was measured as well. Results: The AP and PTH concentrations were higher in CMA patients than in the control group (AP: 610.2 U/L vs. 499.7 U/L, P <0.01; PTH: 1.56 pmol/L vs. 0.83 pmol/L, P <0.03), but all values were in the normal range. The osteocalcin concentration was similar in both groups, and the beta-crosslaps concentration was lower in CMA patients than in controls (0.92 vs. 1.47 ng/mL, P <0.001). The mean Z score of bone mineral density in patients with CMA was -0.6. In 10 cases, the Z score was less than the -1 SD value. On the basis of the Z score, CMA patients were divided into two groups. The PTH concentration was significantly elevated in the group with lower Z score (2.24 pmol/L vs. 1.16 pmol/L; P <0.03). Conclusion: The results suggest that, in children with CMA who are on a cow milk-free diet, slight disturbances of bone mineralization can be observed by osteodensitometry.

KW - Bone mineralization

KW - Child

KW - Cow milk allergy

UR - http://www.scopus.com/inward/record.url?scp=19044363588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19044363588&partnerID=8YFLogxK

U2 - 10.1097/00005176-200301000-00010

DO - 10.1097/00005176-200301000-00010

M3 - Article

C2 - 12499995

AN - SCOPUS:19044363588

VL - 36

SP - 44

EP - 49

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 1

ER -