Sleep promoting effect of a putative glial γ-aminobutyric acid uptake blocker applied in the thalamus of cats

G. Juhász, K. A. Kékesi, Zs Emri, J. Ujszászi, P. Krogsgaard-Larsen, A. Schousboe

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Abstract

The uptake of γ-aminobutyric acid (GABA) by glial cells was decreased when 4,5,6,7,-tetrahydroisoxazolo-(4,5-C)-pyridin-3-ol (THPO) was applied in the thalamus of freely moving cats by in vivo microdialysis. A marked reduction in duration of wakefulness and in number of awakenings was obtained during THPO treatment. THPO did not change the ratio of slow-wave-sleep and paradoxical sleep but only increased the total sleep time. The present data suggest a possible regulatory role.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalEuropean Journal of Pharmacology
Volume209
Issue number1-2
DOIs
Publication statusPublished - Dec 10 1991

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Keywords

  • (Cat) of the glial-neuronal interaction in the modification of the sleep-waking cycle
  • GABA (γ-aminobutyric acid)
  • Glial uptake
  • Sleep
  • Thalamus

ASJC Scopus subject areas

  • Pharmacology

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