Alvás- es eberségzavarok Parkinsonizmussal járó betegségekben.

Translated title of the contribution: Sleep disorders in Parkinson syndromes

Anna Szucs, Gábor Géza Kovács, Narula Lalit, Halász Péter

Research output: Contribution to journalArticle

Abstract

About 90% of neurodegenerative diseases with parkinsonism are associated with sleep disorders including daytime sleepiness, sleep-related breathing disorders and parasomnias. It is hard to define what ratio of insomnia and daytime hypersomnia is caused by the antiparkinsonian treatment, by the somatic and mental-emotional symptoms of the neurodegenerative disease and by the neurodegenerative brain process itself. Recent research suggests that the latter group is more important than expected. In Parkinson syndromes the structures included in sleep regulation--mainly within the brainstem--are also affected resulting in specific sleep disorders being the primary biological symptoms of these diseases. The recently described parasomnia--REM sleep behavior disorder--has a specific significance in this respect: it may prevent by several years a high ratio of the parkinsonian disorders--especially synucleinopathies--offering the possibility of prevention by identifying the affected individuals. There seems to exist a similar although less clarified association between daytime sleepiness and Parkinson disease. Analysing the behavior of the orexin system in neurodegenerative diseases may help to learn more about this, recently described neurohumoral system and may clear the association of narcolepsy with neurodegeneration. By understanding the associations of parkinsonian disorders and sleep disorders new therapeutical strategies may be invented and may offer new aspects to understand the mechanism of them.

Original languageHungarian
Pages (from-to)223-233
Number of pages11
JournalIdeggyógyászati szemle
Volume60
Issue number5-6
Publication statusPublished - May 30 2007

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Parkinsonian Disorders
Parasomnias
Neurodegenerative Diseases
Sleep
REM Sleep Behavior Disorder
Disorders of Excessive Somnolence
Antiparkinson Agents
Narcolepsy
Sleep Initiation and Maintenance Disorders
Brain Stem
Parkinson Disease
Respiration
Brain
Research
Sleep Wake Disorders
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alvás- es eberségzavarok Parkinsonizmussal járó betegségekben. / Szucs, Anna; Kovács, Gábor Géza; Lalit, Narula; Péter, Halász.

In: Ideggyógyászati szemle, Vol. 60, No. 5-6, 30.05.2007, p. 223-233.

Research output: Contribution to journalArticle

Szucs, Anna ; Kovács, Gábor Géza ; Lalit, Narula ; Péter, Halász. / Alvás- es eberségzavarok Parkinsonizmussal járó betegségekben. In: Ideggyógyászati szemle. 2007 ; Vol. 60, No. 5-6. pp. 223-233.
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