Skin microcirculatory changes reflect early the circulatory deterioration in a fulminant sepsis model in the pig

Ferenc Kiss, Levente Molnar, Endre Hajdu, Adam Deak, Abel Molnar, Marianna Berhes, J. Szabó, N. Németh, B. Fülesdi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

PURPOSE: In the pathophysiology of sepsis tissue perfusion dysfunction is a crucial driving force. Thus the early recognition is highly important. Concerning the early hours of bacteremia, and the systemic inflammatory response reaction leading to sepsis we aimed to investigate the micro- and macrocirculatory changes.METHODS: In 20 juvenile Hungahib pigs were anesthetized and the femoral artery and external jugular vein were prepared unilaterally and cannulated. For assisted ventilation tracheostomy was performed. In Sepsis group (n=11) live E. coli was intravenously administered (increasing concentration, 9.5x10^6 in 3h). In Control group (n=9) bacteria-free saline was administered at the same volume. Modified shock index (MSI), core and skin temperature, and skin microcirculation (laser Doppler) were measured before inducing bacteremia then hourly for 4h.RESULTS: In Control group parameters were stable, while six animals in the Sepsis group died before the 4th hour. Core and skin temperature did not show significant alterations. In Sepsis group microcirculation showed a large impairment already by the 1st hour, while in MSI only by the 3rd hour.CONCLUSION: During bacteremia and the early phase of sepsis microcirculatory impairment can be detected soon, even hours before the deterioration in hemodynamic parameters in this porcine model.

Original languageEnglish
Pages (from-to)470-477
Number of pages8
JournalActa Cirurgica Brasileira
Volume30
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

Sepsis
Swine
Skin
Bacteremia
Skin Temperature
Microcirculation
Shock
Control Groups
Tracheostomy
Jugular Veins
Femoral Artery
Ventilation
Lasers
Perfusion
Hemodynamics
Escherichia coli
Bacteria

Keywords

  • Animal
  • Bacteremia
  • Hemodynamics
  • Microcirculation
  • Models
  • Sepsis
  • Shock
  • Swine

ASJC Scopus subject areas

  • Surgery

Cite this

Skin microcirculatory changes reflect early the circulatory deterioration in a fulminant sepsis model in the pig. / Kiss, Ferenc; Molnar, Levente; Hajdu, Endre; Deak, Adam; Molnar, Abel; Berhes, Marianna; Szabó, J.; Németh, N.; Fülesdi, B.

In: Acta Cirurgica Brasileira, Vol. 30, No. 7, 01.07.2015, p. 470-477.

Research output: Contribution to journalArticle

Kiss, Ferenc ; Molnar, Levente ; Hajdu, Endre ; Deak, Adam ; Molnar, Abel ; Berhes, Marianna ; Szabó, J. ; Németh, N. ; Fülesdi, B. / Skin microcirculatory changes reflect early the circulatory deterioration in a fulminant sepsis model in the pig. In: Acta Cirurgica Brasileira. 2015 ; Vol. 30, No. 7. pp. 470-477.
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AU - Deak, Adam

AU - Molnar, Abel

AU - Berhes, Marianna

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