Skin immune system

István Nagy, Lajos Kemény

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The epidermis has a powerful innate immune system. Keratinocytes are immunologically active cells, able to identify and kill invading microbes. Keratinocytes recognize highly conserved structures of the pathogens, called pathogenassociated molecular patterns (PAMPs), via pattern recognition receptors (PRRs), which results in the secretion of antimicrobial and proinflammatory mediators. Antimicrobial peptides and proinflammatory chemokines/cytokines, effector molecules of innate immunity, also act as regulators of acquired immune responses, inflammation and wound repair. Keratinocyte-derived effector molecules are critical in the recruitment of dendritic cells, T cells and neutrophils into sites of infection, linking innate and acquired immune responses in the skin.

Original languageEnglish
Title of host publicationLife-Threatening Dermatoses and Emergencies in Dermatology
PublisherSpringer Berlin Heidelberg
Pages19-28
Number of pages10
ISBN (Print)9783540793380
DOIs
Publication statusPublished - Dec 1 2009

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nagy, I., & Kemény, L. (2009). Skin immune system. In Life-Threatening Dermatoses and Emergencies in Dermatology (pp. 19-28). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-79339-7_2