Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice

G. Kökény, M. Godó, E. Nagy, M. Kardos, K. Kotsch, P. Casalis, C. Bodor, L. Rosivall, H. D. Volk, A. C. Zenclussen, P. Hamar

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The role of pregnancy in the progression of systemic lupus erythematosus (SLE) is still poorly understood. We analysed the effect of repeated pregnancies in MRL/lpr mice, a murine model of SLE. Seven-week old female mice were used: multiparous mice underwent three consecutive pregnancies (M); age-matched virgin mice served as controls (V). Animals were harvested at 20 weeks of age. Skin lesions were characterized by hair loss and scabs in the dorsum of the neck. Virgin skins showed thickened dermis, fibrosis and mononuclear cell infiltrates, which were practically absent in M. This was accompanied by higher IFN-γ and lower IL-10 mRNA expression levels in V compared to M skin. Plasma IFN-γ protein levels were also upregulated in V versus M. However, survival and kidney function were dramatically reduced and accompanied by hypertension after multiple pregnancies. Kidney histology also showed markedly increased renal lesions in M. In contrast to plasma and skin levels, both IL-10 and IFN-γ mRNA were lower in the kidneys of V versus M mice. Concluding our findings, the pathomechanisms of lupus kidney and skin disease may be regulated differently at the organ level during pregnancy. Both IFN-γ and IL-10 may be important regulatory cytokines at the local level.

Original languageEnglish
Pages (from-to)465-477
Number of pages13
JournalLupus
Volume16
Issue number7
DOIs
Publication statusPublished - 2007

Fingerprint

Multiple Pregnancy
Nephritis
Skin Diseases
Interleukin-10
Kidney
Pregnancy
Skin
Systemic Lupus Erythematosus
Inbred MRL lpr Mouse
Messenger RNA
Alopecia
Kidney Diseases
Dermis
Blood Proteins
Histology
Fibrosis
Neck
Cytokines
Hypertension

Keywords

  • Cytokines
  • Kidney
  • Mouse
  • Skin
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice. / Kökény, G.; Godó, M.; Nagy, E.; Kardos, M.; Kotsch, K.; Casalis, P.; Bodor, C.; Rosivall, L.; Volk, H. D.; Zenclussen, A. C.; Hamar, P.

In: Lupus, Vol. 16, No. 7, 2007, p. 465-477.

Research output: Contribution to journalArticle

Kökény, G, Godó, M, Nagy, E, Kardos, M, Kotsch, K, Casalis, P, Bodor, C, Rosivall, L, Volk, HD, Zenclussen, AC & Hamar, P 2007, 'Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice', Lupus, vol. 16, no. 7, pp. 465-477. https://doi.org/10.1177/0961203307079456
Kökény, G. ; Godó, M. ; Nagy, E. ; Kardos, M. ; Kotsch, K. ; Casalis, P. ; Bodor, C. ; Rosivall, L. ; Volk, H. D. ; Zenclussen, A. C. ; Hamar, P. / Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice. In: Lupus. 2007 ; Vol. 16, No. 7. pp. 465-477.
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